Bodor, Dani LJansen, Lars E T2016-05-242016-05-242013-06-21Bodor, D. L., Jansen, L. E. T. (2013). How two become one: HJURP dimerization drives CENP-A assembly. EMBO J., 32(15), 2090–2092.http://hdl.handle.net/10400.7/618CENP‐A containing nucleosomes epigenetically specify centromere position on chromosomes. Deposition of CENP‐A into chromatin is mediated by HJURP, a specific CENP‐A chaperone. Paradoxically, HJURP binding sterically prevents dimerization of CENP‐A, which is critical to form functional centromeric nucleosomes. A recent publication in The EMBO Journal (Zasadzińska et al, 2013) demonstrates that HJURP itself dimerizes through a C‐terminal repeat region, which is essential for centromeric assembly of nascent CENP‐A.engAutoantigensCentromereChromosomal Proteins, Non-HistoneDNA-Binding ProteinsHumansNucleosomesProtein Multimerizationjournal article10.1038/emboj.2013.150