Bergman, Marie-LouiseLopes-Carvalho, ThiagoMartins, Ana-CatarinaGrieco, Fabio A.Eizirik, Décio L.Demengeot, Jocelyne2017-12-072017-12-072017-05-23Tolerogenic insulin peptide therapy precipitates type 1 diabetes Marie-Louise Bergman, Thiago Lopes-Carvalho, Ana-Catarina Martins, Fabio A. Grieco, Décio L. Eizirik, Jocelyne Demengeot Journal of Experimental Medicine Jul 2017, 214 (7) 2153-2156; DOI: 10.1084/jem.20160471http://hdl.handle.net/10400.7/819This deposit is composed by the main article plus the supplementary materials of the publication.Daniel et al. (https://doi.org/10.1084/jem.20110574) have previously published in JEM a study on the preventive effect of tolerogenic vaccination with a strong agonist insulin mimetope in type 1 diabetes. Our study now challenges these results and shows that osmotic pump delivery of the modified insulin peptide R22E did not prevent hyperglycemia, accelerated disease onset, increased its incidence, and worsened insulitis.engAutoimmunitydiabetesinsulinVaccinationreview10.1084/jem.20160471