Asymptomatic Plasmodium falciparum infection in children is associated with increased auto-antibody production, high IL-10 plasma levels and antibodies to merozoite surface protein 3

Guiyedi, VincentBécavin, ChristopheHerbert, FabienGray, JulianCazenave, Pierre-AndréKombila, MaryvonneCrisanti, AndreaFesel, ConstantinPied, Sylviane2015-10-202015-10-202015-04-16http://hdl.handle.net/10400.7/413Mechanisms of acquired protection to malaria in asymptomatic Plasmodium falciparum carriers are only partially understood. Among them, the role plays by the self-reactive antibodies has not been clarified yet. In this study, the relationship between repertoires of circulating self-reactive and parasite-specific immunoglobulin G (IgG), their correlation with cytokine levels, and their association with protection against malaria was investigated in asymptomatic Plasmodium falciparum-infected Gabonese children.engAuto-antibodyAntibody responsePlasmodium falciparumMalariaCytokinesAsymptomatic Plasmodium falciparum infection in children is associated with increased auto-antibody production, high IL-10 plasma levels and antibodies to merozoite surface protein 3journal article10.1186/s12936-015-0658-7