Carvalho, Thiago L.Mota-Santos, TomazCumano, AnaDemengeot, JocelynePaulo, Vieira2010-07-202010-07-202001-10-15Carvalho, T.L., Mota-Santos T., Cumano A., Demergeot J., Vieira P. (2001) " Arrested B Lymphopoiesis and Persistence of Activated B Cells in Adult Interleukin 7". Journal of Experimental Medicine. 194 (8):1141-1150 OCT0022-1007http://hdl.handle.net/10400.7/132This deposit is composed by a publication in which the IGC' authors have had the role of collaboration (it's a collaboration publication). This type of deposit in ARCA is in restrictedAccess (it can't be in open access to the public), and could only be accessed by two ways: either by requesting a legal copy to the author (the email contact present in this deposit) or by visiting the following link: https://f1000.com/prime/1003667Interleukin 7 is a crucial factor for the development of murine T and B lymphocytes. We now report that, in the absence of interleukin 7, B lymphocyte production takes place exclusively during fetal and perinatal life, ceasing after 7 wk of age. In peripheral organs, however, the pool of B lymphocytes is stable throughout adult life and consists only of cells that belong to the B1 and marginal zone (MZ) compartments. This is accompanied by a 50-fold increase in the frequency of immunoglobulin (Ig)M- and IgG-secreting cells, and the concentration of serum immunoglobulins is increased three- to fivefold. Both the MZ phenotype and the increase in serum IgM are T cell independent. These findings reveal a previously undescribed pathway of B lymphopoiesis that is active in early life and is interleukin 7 independent. This pathway generates B1 cells and a normal sized MZ B lymphocyte compartment.engB lymphocyteinterleukin 7marginal zone B cellsB1 cellsB cell developmentjournal article