Stankovic, A.Jansen, L. E. T.2015-11-092015-11-092013-01-07Reductionism at the vertebrate kinetochore Ana Stankovic and Lars E.T. Jansen J Cell Biol 2013 200:7-8. Published December 31, 2012, doi:10.1083/jcb.201212005http://hdl.handle.net/10400.7/482The kinetochore forms the site of attachment for mitotic spindle microtubules driving chromosome segregation. The interdependent protein interactions in this large structure have made it difficult to dissect the function of its components. In this issue, Hori et al. (2013. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201210106) present a novel and powerful methodology to address the sufficiency of individual proteins for the creation of a functional de novo centromere.engAutoantigensChromosomal Proteins, Non-HistoneDNA-Binding ProteinsKinetochoresMultiprotein Complexesjournal article10.1083/jcb.201212005