Schulte, KathrinPawlowski, NikolausFaelber, KatjaFröhlich, ChrisHoward, JonathanDaumke, Oliver2016-03-072016-03-072016-03-02http://hdl.handle.net/10400.7/555The immunity-related GTPases (IRGs) constitute a powerful cell-autonomous resistance system against several intracellular pathogens. Irga6 is a dynamin-like protein that oligomerizes at the parasitophorous vacuolar membrane (PVM) of Toxoplasma gondii leading to its vesiculation. Based on a previous biochemical analysis, it has been proposed that the GTPase domains of Irga6 dimerize in an antiparallel fashion during oligomerization.engInnate immunityIRG proteinsGTPaseDynamin superfamilyDimerizationOligomerizationThe immunity-related GTPase Irga6 dimerizes in a parallel head-to-head fashionjournal article10.1186/s12915-016-0236-7