Costa, NMarques, OGodinho, SCarvalho, CLeal, BVasconcelos, CMarinho, AMoraes-Fontes, M FGomes da Costa, APonte, CMarques, RCoias, TMartins, A RViana, J FMartins, BFesel, C2016-07-082016-07-082014-03A3.6 Two components contributing to reduced treg surface CD25 in sle patients and their unaffected relatives N Costa, O Marques, S Godinho, C Carvalho, B Leal, C Vasconcelos, A Marinho, M F Moraes-Fontes, A Gomes da Costa, C Ponte, R Marques, T Coias, A R Martins, J F Viana, B Martins, C Fesel Ann Rheum Dis 2014;73:Suppl 1 A44 doi:10.1136/annrheumdis-2013-205124.100http://hdl.handle.net/10400.7/677Background FOXP3+ regulatory T-cells (Tregs) in Systemic Lupus Erythematosus (SLE) are in a functionally deficient state with a characteristic reduction or absence of surface CD25 (the IL-2 receptor alpha chain). Genetic variation in the CD25-encoding IL2RA locus is associated with other autoimmune disorders.engSystemic Lupus Erythematosus (SLE)CD25FOXP3+A3.6 Two components contributing to reduced treg surface CD25 in sle patients and their unaffected relativesjournal article10.1136/annrheumdis-2013-205124.100