Guiyedi, V.Chanseaud, Y.Fesel, C.Snounou, G.Rousselle, J.C.Lim, P.Koko, J.Namane, A.Cazenave, P.A.Kombila, M.Pied, S.2011-05-182011-05-182007-04Guiyedi, V, Chanseaud, Y., Fesel C., Snounou G., Rousselle J.-C., Lim P., Koko J., Namane A., Cazenave P.-A., Kombila M., Pied S. (2007) “Self-reactivities to the non-erythroid Alpha Spectrin correlate with cerebral malaria in Gabonese children”. PLOS One. 2(4): e3891932-6203http://hdl.handle.net/10400.7/214http://dx.doi.org/10.1371/journal.pone.0000389Hypergammaglobulinemia and polyclonal B-cell activation commonly occur in Plasmodium sp. infections. Some of the antibodies produced recognize self-components and are correlated with disease severity in P. falciparum malaria. However, it is not known whether some self-reactive antibodies produced during P. falciparum infection contribute to the events leading to cerebral malaria (CM). We show here a correlation between self-antibody responses to a human brain protein and high levels of circulating TNF alpha (TNFα), with the manifestation of CM in Gabonese childrenengImmunoglobulin G/immunologyMalaria, Cerebral/immunologyMalaria, Falciparum/immunologySpectrin/immunologyjournal article