Repositório Colecção:http://hdl.handle.net/10400.7/8612020-03-07T13:42:40Z2020-03-07T13:42:40ZDid Germinal Centers evolve under differential effects of diversity vs affinity?Faro, J.Combadão, J.Gordo, I.http://hdl.handle.net/10400.7/862018-04-11T11:32:40Z2006-01-01T00:00:00ZTítulo: Did Germinal Centers evolve under differential effects of diversity vs affinity?
Autor: Faro, J.; Combadão, J.; Gordo, I.
Resumo: The classical view on the process of mutation and affinity
maturation that occurs in GCs assumes that their major role is to generate
high affinity levels of serum Abs, as well as a dominant pool of high
affinity memory B cells, through a very efficient selection process. Here
we present a model that considers different types of structures where a
mutation selection process occurs, with the aim at discussing the evolution
of Germinal Center reactions. Based on the results of this model, we
suggest that in addition to affinity maturation, the diversity generated
during the GC reaction may have also been important in the evolution towards
the presently observed highly organized structure of GC in higher
vertebrates.2006-01-01T00:00:00Z