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- Increased polyclonal immunoglobulin reactivity toward human and bacterial proteins is associated with clinical protection in human Plasmodium infectionPublication . Fesel, C.; Goulart, L.F.; Neto, A.S.; Coelho, A.; Fontes, C.J.F.; Braga, E.M.; Vaz, N.M.The observed difference in polyclonal antibody production seems related to intrinsic activation states of infected individuals, rather than to parasite-antigen specific immune responses. However, it appears influenced by preceding stimuli. This supports the idea that acquired clinical immunity may not exclusively depend on antigen-specific responses, but also on the individual polyclonal reaction.