ARCA

Gulbenkian Institute of Science Repository

WELCOME TO ARCA, INSTITUTO GULBENKIAN DE CIÊNCIA REPOSITORY

ARCA is a open acess repository. Our gold is to collect, preserve and to promote scientific production of IGC researchers and allow free access to the full text whenever possible.

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Recent Submissions

SnRK1 and trehalose 6-phosphate – two ancient pathways converge to regulate plant metabolism and growth

Publication . Baena-González, Elena; Lunn, John

SUCROSE-NON-FERMENTING1-RELATED KINASE1 (SnRK1) belongs to a family of protein kinases that originated in the earliest eukaryotes and plays a central role in energy and metabolic homeostasis. Trehalose 6-phosphate (Tre6P) is the intermediate of trehalose biosynthesis, and has even more ancient roots, being found in all three domains of life – Archaea, Bacteria and Eukarya. In plants, the function of SnRK1 has diverged from its orthologues in fungi and animals, evolving new roles in signalling of nutrient status and abiotic stress. Tre6P has also acquired a novel function in plants as a signal and homeostatic regulator of sucrose, the dominant sugar in plant metabolism. These two ancient pathways have converged in a unique way in plants, enabling them to coordinate their metabolism, growth and development with their environment, which is essential for their autotrophic and sessile lifestyle

2020-04-04Journal article

Open access

Shaping plant development through the SnRK1–TOR metabolic regulators

Publication . Baena-González, Elena; Hanson, Johannes

SnRK1 (Snf1-related protein kinase 1) and TOR (target ofrapamycin) are evolutionarily conserved protein kinases thatlie at the heart of energy sensing, playing central andantagonistic roles in the regulation of metabolism and geneexpression. Increasing evidence links these metabolicregulators to numerous aspects of plant development, fromgermination to flowering and senescence. This prompts thehypothesis that SnRK1 and TOR modify developmentalprograms according to the metabolic status to adjust plantgrowth to a specific environment. The aim of this review is toprovide support to this hypothesis and to incentivize furtherstudies on this topic by summarizing the work that establishesa genetic connection between SnRK1–TOR and plantdevelopment.

2017-02Journal article

Open access

Epha1 is a cell-surface marker for the neuromesodermal competent population

Publication . de Lemos, Luisa; Dias, André; Nóvoa, Ana; Mallo, Moisés

2022Journal article

Open access

Diet leaves a genetic signature in a keystone member of the gut microbiota

Publication . Dapa, Tanja; Ramiro, Ricardo Serotte; Pedro, Miguel Filipe; Gordo, Isabel; Xavier, Karina Bivar

Switching from a low-fat and high-fiber diet to a Western-style high-fat and high-sugar diet causes microbiota imbalances that underlay many pathological conditions (i.e., dysbiosis). Although the effects of dietary changes on microbiota composition and functions are well documented, their impact in gut bacterial evolution remains unexplored. We followed the emergence of mutations in Bacteroides thetaiotaomicron, a prevalent fiber-degrading microbiota member, upon colonization of the murine gut under different dietary regimens. B. thetaiotaomicron evolved rapidly in the gut and Western-style diet selected for mutations that promote degradation of mucin-derived glycans. Periodic dietary changes caused fluctuations in the frequency of such mutations and were associated with metabolic shifts, resulting in the maintenance of higher intraspecies genetic diversity compared to constant dietary regimens. These results show that dietary changes leave a genetic signature in microbiome members and suggest that B. thetaiotaomicron genetic diversity could be a biomarker for dietary differences among individuals.

2022Journal article

Open access

Isolated Incudostapedial Cholesteatomas: Unique Radiologic and Surgical Features

Publication . MacDonald, Bridget; Bommakanti, Krishna; Mallo, Moises; Carvalho, Daniela

2020Journal article

Open access