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Computational Genomics

URI permanente desta comunidade:

http://hdl.handle.net/10400.7/37

We are interested in the evolutionary mechanisms underlying the origins and evolution of cellular life and the complex structures within the cell, the transitions to multi-cellularity, and the medical applications of evolutionary genomics. Our research encompasses themes that are broadly classified as evolutionary cell biology, systems biology, pathogenomics, and translational or medical bioinformatics

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Percorrer Computational Genomics por assunto "adaptive evolution"

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  • Evolutionary cell biology: two origins, one objective
    Publication . Lynch, Michael; Field, Mark C; Goodson, Holly V; Malik, Harmit S; Pereira-Leal, José B; Roos, David S; Turkewitz, Aaron P; Sazer, Shelley
    All aspects of biological diversification ultimately trace to evolutionary modifications at the cellular level. This central role of cells frames the basic questions as to how cells work and how cells come to be the way they are. Although these two lines of inquiry lie respectively within the traditional provenance of cell biology and evolutionary biology, a comprehensive synthesis of evolutionary and cell-biological thinking is lacking. We define evolutionary cell biology as the fusion of these two eponymous fields with the theoretical and quantitative branches of biochemistry, biophysics, and population genetics. The key goals are to develop a mechanistic understanding of general evolutionary processes, while specifically infusing cell biology with an evolutionary perspective. The full development of this interdisciplinary field has the potential to solve numerous problems in diverse areas of biology, including the degree to which selection, effectively neutral processes, historical contingencies, and/or constraints at the chemical and biophysical levels dictate patterns of variation for intracellular features. These problems can now be examined at both the within- and among-species levels, with single-cell methodologies even allowing quantification of variation within genotypes. Some results from this emerging field have already had a substantial impact on cell biology, and future findings will significantly influence applications in agriculture, medicine, environmental science, and synthetic biology.
    2014-12-02Artigo científico Acesso aberto Ver mais