Molecular mechanisms of induced protection against sepsis by DNA damage responses

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Changes in Expression of the CLOCK Gene in Obstructive Sleep Apnea Syndrome Patients Are Not Reverted by Continuous Positive Airway Pressure Treatment

Publication . Moreira, Susana; Rodrigues, Raquel; Barros, André B.; Pejanovic, Nadja; Neves-Costa, Ana; Pedroso, Dora; Pereira, Cláudia; Fernandes, Dina; Rodrigues, João Valença; Barbara, Cristina; Moita, Luís Ferreira

Metabolic syndrome and cardiovascular disease are strongly associated with obstructive sleep apnea syndrome (OSAS), which causes substantial changes to normal circadian physiological functions, including metabolic pathways. Because core clock genes are known to be modulated by sleep/vigilance cycles, we asked whether the expression level of mRNA coding for clock genes is altered in non-treated OSAS patients and if it can be corrected by standard continuous positive airway pressure (CPAP) treatment.

2017-11-06Artigo científico

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Entidade financiadora

European Commission

Programa de financiamento

H2020

Número da atribuição

647888