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Disease tolerance and immunity in host protection against infection

2017-02Journal article Open access
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dc.contributor.authorSoares, Miguel P.
dc.contributor.authorTeixeira, Luis
dc.contributor.authorMoita, Luis F.
dc.date.accessioned2017-06-22T11:17:37Z
dc.date.available2017-08-03T00:30:08Z
dc.date.issued2017-02
dc.descriptionThe deposited article is a pre-print version.pt_PT
dc.descriptionThis publication hasn't any creative commons license associated.pt_PT
dc.descriptionThis deposit is composed by the main article which contains attached the supplementary materials.pt_PT
dc.description.abstractThe immune system probably evolved to limit the negative effects exerted by pathogens on host homeostasis. This defence strategy relies on the concerted action of innate and adaptive components of the immune system, which sense and target pathogens for containment, destruction or expulsion. Resistance to infection refers to these immune functions, which reduce the pathogen load of an infected host as the means to preserve homeostasis. Immune-driven resistance to infection is coupled to an additional, and arguably as important, defence strategy that limits the extent of dysfunction imposed on host parenchymal tissues during infection, without exerting a direct negative effect on pathogens. This defence strategy, known as disease tolerance, relies on tissue damage control mechanisms that prevent the deleterious effects of pathogens and that uncouples immune-driven resistance mechanisms from immunopathology and disease. In this Review, we provide a unifying view of resistance and disease tolerance in the framework of immunity to infection.pt_PT
dc.description.sponsorshipInstituto Gulbenkian de Ciência; Fundação Calouste Gulbenkian; Fundação para a Ciência e Tecnologia grants: (PTDC/SAU-TOX/116627/2010, HMSP-ICT/0022/2010, PTDC/BEX-GMG/3128/2014); ERC grants: (ERC-2011-AdG 294709-DAMAGECONTROL, ERC-2014-CoG 647888-iPROTECTION).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSoares, M.P., Teixeira, L., Moita, L.F. (2017) Disease Tolerance And Immunity In Host Protection Against Infection. Nat. Rev. Immunol. 17(2): 83-96. doi: 10.1038/nri.2016.136pt_PT
dc.identifier.doi10.1038/nri.2016.136pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/767
dc.language.isoengpt_PT
dc.peerreviewednopt_PT
dc.publisherNature Publishing Grouppt_PT
dc.relationHMSP-ICT/0022/2010pt_PT
dc.relationERC-2014-CoG 647888-iPROTECTIONpt_PT
dc.relationTissue Damage Control Regulates The Pathogenesis of Immune Mediated Inflammatory Diseases
dc.relation.publisherversionhttps://www.nature.com/nri/journal/v17/n2/full/nri.2016.136.htmlpt_PT
dc.subjectAntimicrobial responsespt_PT
dc.subjectInfectionpt_PT
dc.subjectInflammationpt_PT
dc.subjectLymphoid tissuespt_PT
dc.titleDisease tolerance and immunity in host protection against infectionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleTissue Damage Control Regulates The Pathogenesis of Immune Mediated Inflammatory Diseases
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-TOX%2F116627%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/294709/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBEX-GMG%2F3128%2F2014/PT
oaire.citation.endPage96pt_PT
oaire.citation.issue2pt_PT
oaire.citation.startPage83pt_PT
oaire.citation.titleNature Reviews Immunologypt_PT
oaire.citation.volume17pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamFP7
oaire.fundingStream3599-PPCDT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication72d8fa6f-1215-4a61-bc70-515eef334d45
relation.isProjectOfPublication370f9aad-c4ef-4e35-b754-edc840dc6b5e
relation.isProjectOfPublicationc4809a58-1420-4b1a-86f6-e84a0f1f41de
relation.isProjectOfPublication.latestForDiscovery370f9aad-c4ef-4e35-b754-edc840dc6b5e

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