dc.contributor.author	Maric-Biresev, Jelena
dc.contributor.author	Hunn, Julia P.
dc.contributor.author	Krut, Oleg
dc.contributor.author	Helms, J. Bernd
dc.contributor.author	Martens, Sascha
dc.contributor.author	Howard, Jonathan C.
dc.date.accessioned	2016-04-26T11:30:44Z
dc.date.available	2016-04-26T11:30:44Z
dc.date.issued	2016-04-20
dc.description.abstract	The interferon-γ (IFN-γ)-inducible immunity-related GTPase (IRG), Irgm1, plays an essential role in restraining activation of the IRG pathogen resistance system. However, the loss of Irgm1 in mice also causes a dramatic but unexplained susceptibility phenotype upon infection with a variety of pathogens, including many not normally controlled by the IRG system. This phenotype is associated with lymphopenia, hemopoietic collapse, and death of the mouse.	pt_PT
dc.description.sponsorship	Deutscher Akademischer Austausch Dienst (DAAD); International Graduate School in Development Health and Disease (IGS-DHD); Deutsche For-schungsgemeinschaft (SFBs 635, 670, 680); Max-Planck-Gesellschaft (Max Planck Fellowship).	pt_PT
dc.identifier.citation	Maric-Biresev, J., Hunn, J. P., Krut, O., Helms, J. B., Martens, S., Howard, J. C. (2016). Loss of the interferon-γ-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activation of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic susceptibility of Irgm1-deficient mice to infection. BMC Biology, 14, 33.	pt_PT
dc.identifier.doi	10.1186/s12915-016-0255-4	pt_PT
dc.identifier.uri	http://hdl.handle.net/10400.7/581
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	BioMed Central	pt_PT
dc.relation.publisherversion	http://bmcbiol.biomedcentral.com/articles/10.1186/s12915-016-0255-4	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	pt_PT
dc.subject	Immunity-related GTPases	pt_PT
dc.subject	IRGs	pt_PT
dc.subject	Pathogen recognition	pt_PT
dc.subject	Irgm1	pt_PT
dc.subject	Irgm3	pt_PT
dc.subject	Lysosomes	pt_PT
dc.subject	Autophagy	pt_PT
dc.title	Loss of the interferon-γ-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activation of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic susceptibility of Irgm1-deficient mice to infection	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.citation.endPage	20	pt_PT
oaire.citation.issue	1	pt_PT
oaire.citation.startPage	1	pt_PT
oaire.citation.title	BMC Biology	pt_PT
oaire.citation.volume	14	pt_PT
rcaap.rights	openAccess	pt_PT
rcaap.type	article	pt_PT

Loss of the interferon-γ-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activation of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic susceptibility of Irgm1-deficient mice to infection

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