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Loss of the interferon-γ-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activation of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic susceptibility of Irgm1-deficient mice to infection

2016-04-20Journal article Open access
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dc.contributor.authorMaric-Biresev, Jelena
dc.contributor.authorHunn, Julia P.
dc.contributor.authorKrut, Oleg
dc.contributor.authorHelms, J. Bernd
dc.contributor.authorMartens, Sascha
dc.contributor.authorHoward, Jonathan C.
dc.date.accessioned2016-04-26T11:30:44Z
dc.date.available2016-04-26T11:30:44Z
dc.date.issued2016-04-20
dc.description.abstractThe interferon-γ (IFN-γ)-inducible immunity-related GTPase (IRG), Irgm1, plays an essential role in restraining activation of the IRG pathogen resistance system. However, the loss of Irgm1 in mice also causes a dramatic but unexplained susceptibility phenotype upon infection with a variety of pathogens, including many not normally controlled by the IRG system. This phenotype is associated with lymphopenia, hemopoietic collapse, and death of the mouse.pt_PT
dc.description.sponsorshipDeutscher Akademischer Austausch Dienst (DAAD); International Graduate School in Development Health and Disease (IGS-DHD); Deutsche For-schungsgemeinschaft (SFBs 635, 670, 680); Max-Planck-Gesellschaft (Max Planck Fellowship).pt_PT
dc.identifier.citationMaric-Biresev, J., Hunn, J. P., Krut, O., Helms, J. B., Martens, S., Howard, J. C. (2016). Loss of the interferon-γ-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activation of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic susceptibility of Irgm1-deficient mice to infection. BMC Biology, 14, 33.pt_PT
dc.identifier.doi10.1186/s12915-016-0255-4pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/581
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBioMed Centralpt_PT
dc.relation.publisherversionhttp://bmcbiol.biomedcentral.com/articles/10.1186/s12915-016-0255-4pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectImmunity-related GTPasespt_PT
dc.subjectIRGspt_PT
dc.subjectPathogen recognitionpt_PT
dc.subjectIrgm1pt_PT
dc.subjectIrgm3pt_PT
dc.subjectLysosomespt_PT
dc.subjectAutophagypt_PT
dc.titleLoss of the interferon-γ-inducible regulatory immunity-related GTPase (IRG), Irgm1, causes activation of effector IRG proteins on lysosomes, damaging lysosomal function and predicting the dramatic susceptibility of Irgm1-deficient mice to infectionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage20pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleBMC Biologypt_PT
oaire.citation.volume14pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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