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Aurora at the pole and equator: overlapping functions of Aurora kinases in the mitotic spindle

dc.contributor.authorHochegger, H.
dc.contributor.authorHegarat, N.
dc.contributor.authorPereira-Leal, J. B.
dc.date.accessioned2015-10-30T11:24:42Z
dc.date.available2015-10-30T11:24:42Z
dc.date.issued2013-03-20
dc.description.abstractThe correct assembly and timely disassembly of the mitotic spindle is crucial for the propagation of the genome during cell division. Aurora kinases play a central role in orchestrating bipolar spindle establishment, chromosome alignment and segregation. In most eukaryotes, ranging from amoebas to humans, Aurora activity appears to be required both at the spindle pole and the kinetochore, and these activities are often split between two different Aurora paralogues, termed Aurora A and B. Polar and equatorial functions of Aurora kinases have generally been considered separately, with Aurora A being mostly involved in centrosome dynamics, whereas Aurora B coordinates kinetochore attachment and cytokinesis. However, double inactivation of both Aurora A and B results in a dramatic synergy that abolishes chromosome segregation. This suggests that these two activities jointly coordinate mitotic progression. Accordingly, recent evidence suggests that Aurora A and B work together in both spindle assembly in metaphase and disassembly in anaphase. Here, we provide an outlook on these shared functions of the Auroras, discuss the evolution of this family of mitotic kinases and speculate why Aurora kinase activity may be required at both ends of the spindle microtubules.pt_PT
dc.identifier10.1098/rsob.120185
dc.identifier.citationHochegger H, He ́ garat N, Pereira-Leal JB. 2013 Aurora at the pole and equator: overlapping functions of Aurora kinases in the mitotic spindle. Open Biol 3: 120185. http://dx.doi.org/10.1098/rsob.120185pt_PT
dc.identifier.doi10.1098/rsob.120185
dc.identifier.urihttp://hdl.handle.net/10400.7/454
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherThe Royal Societypt_PT
dc.relationNo funding declared.pt_PT
dc.relation.publisherversionhttp://rsob.royalsocietypublishing.org/content/3/3/120185pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAurora Kinasespt_PT
dc.subjectmicrotubulespt_PT
dc.subjectchromosome segregationpt_PT
dc.subjectkinesinpt_PT
dc.subjectAurora evolutionpt_PT
dc.titleAurora at the pole and equator: overlapping functions of Aurora kinases in the mitotic spindlept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage13pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleOpen Biologypt_PT
oaire.citation.volume3pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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