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GABA signalling modulates plant growth by directly regulating the activity of plant-specific anion transporters

2015-07-29Journal article Open access
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dc.contributor.authorRamesh, Sunita A.
dc.contributor.authorTyerman, Stephen D.
dc.contributor.authorXu, Bo
dc.contributor.authorBose, Jayakumar
dc.contributor.authorKaur, Satwinder
dc.contributor.authorConn, Vanessa
dc.contributor.authorDomingos, Patricia
dc.contributor.authorUllah, Sana
dc.contributor.authorWege, Stefanie
dc.contributor.authorShabala, Sergey
dc.contributor.authorFeijó, José A.
dc.contributor.authorRyan, Peter R.
dc.contributor.authorGillham, Matthew
dc.date.accessioned2017-02-15T18:16:49Z
dc.date.available2017-02-15T18:16:49Z
dc.date.issued2015-07-29
dc.description.abstractThe non-protein amino acid, gamma-aminobutyric acid (GABA) rapidly accumulates in plant tissues in response to biotic and abiotic stress, and regulates plant growth. Until now it was not known whether GABA exerts its effects in plants through the regulation of carbon metabolism or via an unidentified signalling pathway. Here, we demonstrate that anion flux through plant aluminium-activated malate transporter (ALMT) proteins is activated by anions and negatively regulated by GABA. Site-directed mutagenesis of selected amino acids within ALMT proteins abolishes GABA efficacy but does not alter other transport properties. GABA modulation of ALMT activity results in altered root growth and altered root tolerance to alkaline pH, acid pH and aluminium ions. We propose that GABA exerts its multiple physiological effects in plants via ALMT, including the regulation of pollen tube and root growth, and that GABA can finally be considered a legitimate signalling molecule in both the plant and animal kingdoms.pt_PT
dc.description.sponsorshipAustralian Research Council; Waite Research Institute grants: (FT130100709, DP130104205, CE140100008); Fundação para a Ciência e Tecnologia grant: (PTDC/BEX-BCM/0376/2012); University of Maryland.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationRamesh, S. A. et al. GABA signalling modulates plant growth by directly regulating the activity of plant-specific anion transporters. Nat. Commun. 6:7879 doi: 10.1038/ncomms8879 (2015).pt_PT
dc.identifier.doi10.1038/ncomms8879pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/732
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNature Publishing Grouppt_PT
dc.relation.publisherversionhttp://www.nature.com/articles/ncomms8879pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectPlant physiologypt_PT
dc.subjectPlant signallingpt_PT
dc.subjectPlant transporterspt_PT
dc.titleGABA signalling modulates plant growth by directly regulating the activity of plant-specific anion transporterspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-PLA%2F4018%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F69168%2F2010/PT
oaire.citation.endPage9pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleNature Communicationspt_PT
oaire.citation.volume6pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamSFRH
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication8869b2a9-f7d7-4481-9d6b-9c18f6408fb4
relation.isProjectOfPublicatione787ada0-8597-44ff-966b-e345ed7f252b
relation.isProjectOfPublication.latestForDiscoverye787ada0-8597-44ff-966b-e345ed7f252b

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