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Scaling, genetic drift and clonal interference in the extinction pattern of asexual populations

2005-07-05Journal article Open access
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dc.contributor.authorRosas, A.
dc.contributor.authorGordo, I.
dc.contributor.authorCampos, P.R.A.
dc.date.accessioned2010-03-25T16:15:45Z
dc.date.available2010-03-25T16:15:45Z
dc.date.issued2005-07-05
dc.description.abstractWe investigate the dynamics of loss of favorable mutations in an asexual haploid population. In the current work, we consider homogeneous as well as spatially structured population models. We focus our analysis on statistical measurements of the probability distribution of the maximum population size N(sb) achieved by those mutations that have not reached fixation. Our results show a crossover behavior which demonstrates the occurrence of two evolutionary regimes. In the first regime, which takes place for small N(sb) , the probability distribution is described by a power law with characteristic exponent theta(d) =1.8 +/- 0.01. This power law is not influenced by the rate of beneficial mutations. The second regime, which occurs for intermediate to large values of N(sb), has a characteristic exponent theta(c) which increases as the rate of beneficial mutations grows. These results establish where genetic drift and clonal interference become the main underlying mechanism in the extinction of advantageous mutations.pt
dc.identifier.citationRosas, A., I.Gordo and P.R.A. Campos (2005) Scaling, genetic drift and clonal interference in the extinction pattern of asexual populations. Phys.Rev. E 72, 012901pt
dc.identifier.doi10.1103/PhysRevE.72.012901pt_PT
dc.identifier.issn1744-9561
dc.identifier.urihttp://hdl.handle.net/10400.7/92
dc.language.isoengpt
dc.publisherAmerican Physical Societypt
dc.relation.publisherversionhttps://www.ncbi.nlm.nih.gov/pubmed/16090018
dc.subjectExtinction, Psychologicalpt
dc.subjectGenetic Driftpt
dc.subjectGenetics, Populationpt
dc.subjectReproduction, Asexualpt
dc.titleScaling, genetic drift and clonal interference in the extinction pattern of asexual populationspt
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage012901-4pt
oaire.citation.startPage012901-1pt
oaire.citation.titlePhysical Reviewpt
rcaap.rightsopenAccesspt
rcaap.typearticlept

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