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Multiple Resistance at No Cost: Rifampicin and Streptomycin a Dangerous Liaison in the Spread of Antibiotic Resistance

2015-10Journal article Open access
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dc.contributor.authorDurão, Paulo
dc.contributor.authorTrindade, Sandra
dc.contributor.authorSousa, Ana
dc.contributor.authorGordo, Isabel
dc.date.accessioned2015-12-21T17:43:04Z
dc.date.available2016-10-01T00:30:08Z
dc.date.issued2015-10
dc.description.abstractEvidence is mounting that epistasis is widespread among mutations. The cost of carrying two deleterious mutations, or the advantage of acquiring two beneficial alleles, is typically lower that the sum of their individual effects. Much less is known on epistasis between beneficial and deleterious mutations, even though this is key to the amount of genetic hitchhiking that may occur during evolution. This is particularly important in the context of antibiotic resistance: Most resistances are deleterious, but some can be beneficial and remarkably rifampicin resistance can emerge de novo in populations evolving without antibiotics. Here we show pervasive positive pairwise epistasis on Escherichia coli fitness between beneficial mutations, which confer resistance to rifampicin, and deleterious mutations, which confer resistance to streptomycin. We find that 65% of double resistant strains outcompete sensitive bacteria in an environment devoid of antibiotics. Weak beneficial mutations may therefore overcome strong deleterious mutations and can even render double mutants strong competitors.pt_PT
dc.description.sponsorshipLAO/ITQB, FCT.pt_PT
dc.identifier.citationPaulo Durão, Sandra Trindade, Ana Sousa, and Isabel Gordo Multiple Resistance at No Cost: Rifampicin and Streptomycin a Dangerous Liaison in the Spread of Antibiotic Resistance Mol Biol Evol (2015) 32 (10): 2675-2680 first published online June 30, 2015 doi:10.1093/molbev/msv143pt_PT
dc.identifier.doi10.1093/molbev/msv143pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/538
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherOxford University Presspt_PT
dc.relationMicrobial adaptation within ecosystems
dc.relation.publisherversionhttp://mbe.oxfordjournals.org/content/32/10/2675.longpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/pt_PT
dc.subjectepistasispt_PT
dc.subjectresistancept_PT
dc.subjectmutationpt_PT
dc.titleMultiple Resistance at No Cost: Rifampicin and Streptomycin a Dangerous Liaison in the Spread of Antibiotic Resistancept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMicrobial adaptation within ecosystems
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-EVF%2F114622%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/260421/EU
oaire.citation.endPage16pt_PT
oaire.citation.issue10pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleMolecular Biology and Evolutionpt_PT
oaire.citation.volume32pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamFP7
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationd59762ac-c556-4604-9c9f-9fd4126b56d7
relation.isProjectOfPublication1f01df05-f8af-4e76-8dec-0fc6237b41fd
relation.isProjectOfPublication.latestForDiscovery1f01df05-f8af-4e76-8dec-0fc6237b41fd

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