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SnRK1-triggered switch of bZIP63 dimerization mediates the low-energy response in plants

2015-08-11Journal article Open access
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dc.contributor.authorPedrotti, Lorenzo
dc.contributor.authorWurzinger, Bernhard
dc.contributor.authorAnrather, Dorothea
dc.contributor.authorSimeunovic, Andrea
dc.contributor.authorWeiste, Christoph
dc.contributor.authorValerio, Concetta
dc.contributor.authorDietrich, Katrin
dc.contributor.authorKirchler, Tobias
dc.contributor.authorNägele, Thomas
dc.contributor.authorVicente Carbajosa, Jesús
dc.contributor.authorHanson, Johannes
dc.contributor.authorBaena-González, Elena
dc.contributor.authorChaban, Christina
dc.contributor.authorWeckwerth, Wolfram
dc.contributor.authorDröge-Laser, Wolfgang
dc.contributor.authorTeige, Markus
dc.date.accessioned2016-05-17T15:19:03Z
dc.date.available2016-05-17T15:19:03Z
dc.date.issued2015-08-11
dc.description.abstractMetabolic adjustment to changing environmental conditions, particularly balancing of growth and defense responses, is crucial for all organisms to survive. The evolutionary conserved AMPK/Snf1/SnRK1 kinases are well-known metabolic master regulators in the low-energy response in animals, yeast and plants. They act at two different levels: by modulating the activity of key metabolic enzymes, and by massive transcriptional reprogramming. While the first part is well established, the latter function is only partially understood in animals and not at all in plants. Here we identified the Arabidopsis transcription factor bZIP63 as key regulator of the starvation response and direct target of the SnRK1 kinase. Phosphorylation of bZIP63 by SnRK1 changed its dimerization preference, thereby affecting target gene expression and ultimately primary metabolism. A bzip63 knock-out mutant exhibited starvation-related phenotypes, which could be functionally complemented by wild type bZIP63, but not by a version harboring point mutations in the identified SnRK1 target sites.pt_PT
dc.description.sponsorshipAustrian Science Fund (FWF) grant: (P23435); Deutsche Forschungsgemeinschaft grant (HA2146/8-2); FCT grants: (PTDC/BIA-PLA/3937/2012, UID/Multi/0455½013).pt_PT
dc.identifier.citationeLife 2015;4:e05828pt_PT
dc.identifier.doi10.7554/eLife.05828pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/608
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElife Sciences Publicationspt_PT
dc.relationMetabolic Reprogramming by Induction of Transcription
dc.relation.publisherversionhttps://elifesciences.org/content/4/e05828/article-infopt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAdaptation, Physiologicalpt_PT
dc.subjectArabidopsispt_PT
dc.subjectArabidopsis Proteinspt_PT
dc.subjectBasic-Leucine Zipper Transcription Factorspt_PT
dc.subjectGene Knockout Techniquespt_PT
dc.subjectGenetic Complementation Testpt_PT
dc.subjectPhosphorylationpt_PT
dc.subjectProtein Processing, Post-Translationalpt_PT
dc.subjectProtein-Serine-Threonine Kinasespt_PT
dc.subjectGene Expression Regulation, Plantpt_PT
dc.subjectProtein Multimerizationpt_PT
dc.titleSnRK1-triggered switch of bZIP63 dimerization mediates the low-energy response in plantspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMetabolic Reprogramming by Induction of Transcription
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/264474/EU
oaire.citation.endPage33pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleeLifept_PT
oaire.citation.volume4pt_PT
oaire.fundingStreamFP7
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationcf6c4467-aeee-4b37-ac24-10f8395a9d85
relation.isProjectOfPublication.latestForDiscoverycf6c4467-aeee-4b37-ac24-10f8395a9d85

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