Zalpha-domains: At the intersection between RNA editing and innate immunity

Athanasiadis, Alekos

Publication

Zalpha-domains: At the intersection between RNA editing and innate immunity

2012-11-07Journal article

dc.contributor.author	Athanasiadis, Alekos
dc.date.accessioned	2016-05-23T15:21:13Z
dc.date.available	2016-11-07T01:30:08Z
dc.date.issued	2012-11-07
dc.description.abstract	The involvement of A to I RNA editing in antiviral responses was first indicated by the observation of genomic hyper-mutation for several RNA viruses in the course of persistent infections. However, in only a few cases an antiviral role was ever demonstrated and surprisingly, it turns out that ADARs - the RNA editing enzymes - may have a prominent pro-viral role through the modulation/down-regulation of the interferon response. A key role in this regulatory function of RNA editing is played by ADAR1, an interferon inducible RNA editing enzyme. A distinguishing feature of ADAR1, when compared with other ADARs, is the presence of a Z-DNA binding domain, Zalpha. Since the initial discovery of the specific and high affinity binding of Zalpha to CpG repeats in a left-handed helical conformation, other proteins, all related to the interferon response pathway, were shown to have similar domains throughout the vertebrate lineage. What is the biological function of this domain family remains unclear but a significant body of work provides pieces of a puzzle that points to an important role of Zalpha domains in the recognition of foreign nucleic acids in the cytoplasm by the innate immune system. Here we will provide an overview of our knowledge on ADAR1 function in interferon response with emphasis on Zalpha domains.	pt_PT
dc.description.sponsorship	Marie Curie IRG program: (PIRG03-GA-2008-23100); FCT grant: (PTDC/BIA-PRO/112962/2009).	pt_PT
dc.identifier.citation	Alekos Athanasiadis, Zalpha-domains: At the intersection between RNA editing and innate immunity, Seminars in Cell & Developmental Biology, Volume 23, Issue 3, May 2012, Pages 275-280, ISSN 1084-9521, http://dx.doi.org/10.1016/j.semcdb.2011.11.001.	pt_PT
dc.identifier.doi	10.1016/j.semcdb.2011.11.001	pt_PT
dc.identifier.uri	http://hdl.handle.net/10400.7/612
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	Elsivier Science BV	pt_PT
dc.relation.publisherversion	http://www.sciencedirect.com/science/article/pii/S1084952111002242	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	pt_PT
dc.subject	Adenosine Deaminase	pt_PT
dc.subject	Animals	pt_PT
dc.subject	DNA, Viral	pt_PT
dc.subject	DNA, Z-Form	pt_PT
dc.subject	Humans	pt_PT
dc.subject	Nucleic Acid Conformation	pt_PT
dc.subject	Protein Structure, Tertiary	pt_PT
dc.subject	RNA-Binding Proteins	pt_PT
dc.subject	Immunity, Innate	pt_PT
dc.subject	RNA Editing	pt_PT
dc.title	Zalpha-domains: At the intersection between RNA editing and innate immunity	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.citation.endPage	280	pt_PT
oaire.citation.issue	3	pt_PT
oaire.citation.startPage	275	pt_PT
oaire.citation.title	Seminars in Cell & Developmental Biology	pt_PT
oaire.citation.volume	23	pt_PT
rcaap.rights	openAccess	pt_PT
rcaap.type	article	pt_PT