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Changes in Expression of the CLOCK Gene in Obstructive Sleep Apnea Syndrome Patients Are Not Reverted by Continuous Positive Airway Pressure Treatment

2017-11-06Journal article Open access
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dc.contributor.authorMoreira, Susana
dc.contributor.authorRodrigues, Raquel
dc.contributor.authorBarros, André B.
dc.contributor.authorPejanovic, Nadja
dc.contributor.authorNeves-Costa, Ana
dc.contributor.authorPedroso, Dora
dc.contributor.authorPereira, Cláudia
dc.contributor.authorFernandes, Dina
dc.contributor.authorRodrigues, João Valença
dc.contributor.authorBarbara, Cristina
dc.contributor.authorMoita, Luís Ferreira
dc.date.accessioned2017-12-05T16:44:05Z
dc.date.available2017-12-05T16:44:05Z
dc.date.issued2017-11-06
dc.descriptionThis deposit is composed by the main article plus the supplementary materials of the publication.pt_PT
dc.description.abstractMetabolic syndrome and cardiovascular disease are strongly associated with obstructive sleep apnea syndrome (OSAS), which causes substantial changes to normal circadian physiological functions, including metabolic pathways. Because core clock genes are known to be modulated by sleep/vigilance cycles, we asked whether the expression level of mRNA coding for clock genes is altered in non-treated OSAS patients and if it can be corrected by standard continuous positive airway pressure (CPAP) treatment.pt_PT
dc.description.sponsorshipFundação para a Ciência e Tecnologia; European Research Council grant: (ERC-2014-CoG 647888-iPROTECTION).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMoreira S, Rodrigues R, Barros AB, Pejanovic N, Neves-Costa A, Pedroso D, Pereira C, Fernandes D, Rodrigues JV, Barbara C and Moita LF (2017) Changes in Expression of the CLOCK Gene in Obstructive Sleep Apnea Syndrome Patients Are Not Reverted by Continuous Positive Airway Pressure Treatment. Front. Med. 4:187. doi: 10.3389/fmed.2017.00187pt_PT
dc.identifier.doi10.3389/fmed.2017.00187pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/814
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFrontiers Mediapt_PT
dc.relationMolecular mechanisms of induced protection against sepsis by DNA damage responses
dc.relation.publisherversionhttps://www.frontiersin.org/articles/10.3389/fmed.2017.00187/fullpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectobstructive sleep apnea syndromept_PT
dc.subjectclock genespt_PT
dc.subjectcontinuous positive airway pressurept_PT
dc.subjectslow wave sleeppt_PT
dc.subjectMetabolic Syndromept_PT
dc.subjectCircadian Rhythmspt_PT
dc.titleChanges in Expression of the CLOCK Gene in Obstructive Sleep Apnea Syndrome Patients Are Not Reverted by Continuous Positive Airway Pressure Treatmentpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMolecular mechanisms of induced protection against sepsis by DNA damage responses
oaire.awardURIinfo:eu-repo/grantAgreement/EC/H2020/647888/EU
oaire.citation.endPage5pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleFrontiers in Medicinept_PT
oaire.citation.volume4pt_PT
oaire.fundingStreamH2020
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication2e8747a8-bdbb-4a19-90e7-64e1f57d94dd
relation.isProjectOfPublication.latestForDiscovery2e8747a8-bdbb-4a19-90e7-64e1f57d94dd

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