Temporal Control of Leaf Complexity by miRNA-Regulated Licensing of Protein Complexes

Rubio-Somoza, Ignacio; Zhou, Chuan-Miao; Confraria, Ana; Martinho, Claudia; von Born, Patrick; Baena-Gonzalez, Elena; Wang, Jia-Wei; Weigel, Detlef

Publication

Temporal Control of Leaf Complexity by miRNA-Regulated Licensing of Protein Complexes

2014-11-17Journal article

dc.contributor.author	Rubio-Somoza, Ignacio
dc.contributor.author	Zhou, Chuan-Miao
dc.contributor.author	Confraria, Ana
dc.contributor.author	Martinho, Claudia
dc.contributor.author	von Born, Patrick
dc.contributor.author	Baena-Gonzalez, Elena
dc.contributor.author	Wang, Jia-Wei
dc.contributor.author	Weigel, Detlef
dc.date.accessioned	2016-06-07T11:41:24Z
dc.date.available	2016-06-07T11:41:24Z
dc.date.issued	2014-11-17
dc.description.abstract	The tremendous diversity of leaf shapes has caught the attention of naturalists for centuries. In addition to interspecific and intraspecific differences, leaf morphologies may differ in single plants according to age, a phenomenon known as heteroblasty. In Arabidopsis thaliana, the progression from the juvenile to the adult phase is characterized by increased leaf serration. A similar trend is seen in species with more complex leaves, such as the A. thaliana relative Cardamine hirsuta, in which the number of leaflets per leaf increases with age. Although the genetic changes that led to the overall simpler leaf architecture in A. thaliana are increasingly well understood, less is known about the events underlying age-dependent changes within single plants, in either A. thaliana or C. hirsuta. Here, we describe a conserved miRNA transcription factor regulon responsible for an age-dependent increase in leaf complexity. In early leaves, miR319-targeted TCP transcription factors interfere with the function of miR164-dependent and miR164-independent CUC proteins, preventing the formation of serrations in A. thaliana and of leaflets in C. hirsuta. As plants age, accumulation of miR156-regulated SPLs acts as a timing cue that destabilizes TCP-CUC interactions. The destabilization licenses activation of CUC protein complexes and thereby the gradual increase of leaf complexity in the newly formed organs. These findings point to posttranslational interaction between unrelated miRNA-targeted transcription factors as a core feature of these regulatory circuits.	pt_PT
dc.description.sponsorship	European Molecular Biology Organization (EMBO) fellowship; Fundação para a Ciência e a Tecnologia fellowships; EMBO Installation Grant; National Natural Science Foundation of China grants: (31222029, 912173023); State Key Basic Research Program of China grant: (2013CB127000); Deutsche Forschungsgemeinschaft grants: (SPP1530 and a Gottfried Wilhelm Leibniz Award); Max Planck Society.	pt_PT
dc.identifier.citation	Ignacio Rubio-Somoza, Chuan-Miao Zhou, Ana Confraria, Claudia Martinho, Patrick von Born, Elena Baena-Gonzalez, Jia-Wei Wang, Detlef Weigel, Temporal Control of Leaf Complexity by miRNA-Regulated Licensing of Protein Complexes, Current Biology, Volume 24, Issue 22, 17 November 2014, Pages 2714-2719, ISSN 0960-9822, http://dx.doi.org/10.1016/j.cub.2014.09.058.	pt_PT
dc.identifier.doi	10.1016/j.cub.2014.09.058	pt_PT
dc.identifier.uri	http://hdl.handle.net/10400.7/622
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	Cell Press	pt_PT
dc.relation.publisherversion	http://www.sciencedirect.com/science/article/pii/S0960982214012214	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	pt_PT
dc.subject	Arabidopsis	pt_PT
dc.subject	Arabidopsis Proteins	pt_PT
dc.subject	Gene Expression Regulation, Developmental	pt_PT
dc.subject	Gene Expression Regulation, Plant	pt_PT
dc.subject	MicroRNAs	pt_PT
dc.subject	Plant Development	pt_PT
dc.subject	Plant Leaves	pt_PT
dc.subject	Species Specificity	pt_PT
dc.subject	Time Factors	pt_PT
dc.title	Temporal Control of Leaf Complexity by miRNA-Regulated Licensing of Protein Complexes	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.citation.endPage	2719	pt_PT
oaire.citation.issue	22	pt_PT
oaire.citation.startPage	2714	pt_PT
oaire.citation.title	Current Biology	pt_PT
oaire.citation.volume	24	pt_PT
rcaap.rights	openAccess	pt_PT
rcaap.type	article	pt_PT