Repository logo
 
Publication

Quantitative Microscopy Reveals Centromeric Chromatin Stability, Size, and Cell Cycle Mechanisms to Maintain Centromere Homeostasis

2017-08-25Book part Open access
Simple item page
dc.contributor.authorStankovic, Ana
dc.contributor.authorJansen, Lars E. T.
dc.date.accessioned2017-11-23T12:05:45Z
dc.date.available2018-08-30T00:30:08Z
dc.date.issued2017-08-25
dc.descriptionThe deposited item is a book chapter and is part of the series "Centromeres and Kinetochores" published by the publisher Springer Verlag. The deposited book chapter is a post-print version and has been submitted to peer reviewing. There is no public supplementary material available for this publication. This publication hasn't any creative commons license associated.pt_PT
dc.description.abstractCentromeres are chromatin domains specified by nucleosomes containing the histone H3 variant, CENP-A. This unique centromeric structure is at the heart of a strong self-templating epigenetic mechanism that renders centromeres heritable. We review how specific quantitative microscopy approaches have contributed to the determination of the copy number, architecture, size, and dynamics of centromeric chromatin and its associated centromere complex and kinetochore. These efforts revealed that the key to long-term centromere maintenance is the slow turnover of CENP-A nucleosomes, a critical size of the chromatin domain and its cell cycle-coupled replication. These features come together to maintain homeostasis of a chromatin locus that directs its own epigenetic inheritance and facilitates the assembly of the mitotic kinetochore.pt_PT
dc.description.sponsorshipThere are no funders and sponsors indicated explicitly in the document.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationStankovic A., Jansen L.E.T. (2017) Quantitative Microscopy Reveals Centromeric Chromatin Stability, Size, and Cell Cycle Mechanisms to Maintain Centromere Homeostasis. In: Black B. (eds) Centromeres and Kinetochores. Progress in Molecular and Subcellular Biology, vol 56. Springer, Champt_PT
dc.identifier.doi10.1007/978-3-319-58592-5_6pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/812
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherSpringer Verlagpt_PT
dc.relationThere are no funders and sponsors indicated explicitly in the document.pt_PT
dc.relation.publisherversionhttps://link.springer.com/chapter/10.1007%2F978-3-319-58592-5_6pt_PT
dc.subjectMicroscopypt_PT
dc.subjectCentromerept_PT
dc.subjectCell Cyclept_PT
dc.subjectNucleosomespt_PT
dc.subjectHomeostasispt_PT
dc.titleQuantitative Microscopy Reveals Centromeric Chromatin Stability, Size, and Cell Cycle Mechanisms to Maintain Centromere Homeostasispt_PT
dc.typebook part
dspace.entity.typePublication
oaire.citation.endPage162pt_PT
oaire.citation.startPage139pt_PT
oaire.citation.titleProgress in Molecular and Subcellular Biologypt_PT
oaire.citation.volume56pt_PT
rcaap.embargofctThe deposited book chapter has 12 months of embargo period in terms of access, because of the book series's policies and the publisher's copyright policy, which require a period of embargo of 12 months.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typebookPartpt_PT

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
stankovic_ Prog Mol Subcell Biol 2017_postprint.pdf
Size:
1.12 MB
Format:
Adobe Portable Document Format
Description:
Book Chapter
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

EM - Book Chapters