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Peroxisomes are platforms for cytomegalovirus’ evasion from the cellular immune response

2016-05-16Journal article Open access
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dc.contributor.authorMagalhães, Ana Cristina
dc.contributor.authorFerreira, Ana Rita
dc.contributor.authorGomes, Sílvia
dc.contributor.authorVieira, Marta
dc.contributor.authorGouveia, Ana
dc.contributor.authorValença, Isabel
dc.contributor.authorIslinger, Markus
dc.contributor.authorNascimento, Rute
dc.contributor.authorSchrader, Michael
dc.contributor.authorKagan, Jonathan C.
dc.contributor.authorRibeiro, Daniela
dc.date.accessioned2016-06-08T14:34:29Z
dc.date.available2016-06-08T14:34:29Z
dc.date.issued2016-05-16
dc.description.abstractThe human cytomegalovirus developed distinct evasion mechanisms from the cellular antiviral response involving vMIA, a virally-encoded protein that is not only able to prevent cellular apoptosis but also to inhibit signalling downstream from mitochondrial MAVS. vMIA has been shown to localize at mitochondria and to trigger their fragmentation, a phenomenon proven to be essential for the signalling inhibition. Here, we demonstrate that vMIA is also localized at peroxisomes, induces their fragmentation and inhibits the peroxisomal-dependent antiviral signalling pathway. Importantly, we demonstrate that peroxisomal fragmentation is not essential for vMIA to specifically inhibit signalling downstream the peroxisomal MAVS. We also show that vMIA interacts with the cytoplasmic chaperone Pex19, suggesting that the virus has developed a strategy to highjack the peroxisomal membrane proteins' transport machinery. Furthermore, we show that vMIA is able to specifically interact with the peroxisomal MAVS. Our results demonstrate that peroxisomes constitute a platform for evasion of the cellular antiviral response and that the human cytomegalovirus has developed a mechanism by which it is able to specifically evade the peroxisomal MAVS-dependent antiviral signalling.pt_PT
dc.description.sponsorshipFundação para a Ciência e Tecnologia personal fellowships: (SFRH/BPD/77619/2011, SFRH/BPD/103580/2014, SFRH/BD/81223/2011, SFRH/BD/101942/2014); FCT grants: (PTDC-IMI-MIC-0828-2012 - Programa Operacional Temático Factores de Competitividade” (COMPETE) of “Quadro Comunitário de Apoio III”); Fundo Comunitário Europeu (FEDER); BiMED - Institute for Biomedicine grant: (UID/BIM/04501/2013).pt_PT
dc.identifier.citationMagalhães, A. C. et al. Peroxisomes are platforms for cytomegalovirus’ evasion from the cellular immune response. Sci. Rep. 6, 26028; doi: 10.1038/srep26028 (2016).pt_PT
dc.identifier.doi10.1038/srep26028pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/631
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNature Publishing Grouppt_PT
dc.relation.publisherversionhttp://www.nature.com/articles/srep26028pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectImmune evasionpt_PT
dc.subjectPeroxisomespt_PT
dc.titlePeroxisomes are platforms for cytomegalovirus’ evasion from the cellular immune responsept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage14pt_PT
oaire.citation.issue26028pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleScientific Reportspt_PT
oaire.citation.volume6pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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