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Red alert: labile heme is an alarmin

2016-02Journal article Open access
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dc.contributor.authorSoares, Miguel P
dc.contributor.authorBozza, Marcelo T
dc.date.accessioned2017-06-22T16:11:07Z
dc.date.available2018-02-01T01:30:09Z
dc.date.issued2016-02
dc.descriptionThis publication hasn't any creative commons license associated.pt_PT
dc.descriptionThis deposit is composed by the main article, and it hasn't any supplementary materials associated. There is no public supplementary material available.pt_PT
dc.descriptionThe deposited article is a pre-print version.pt_PT
dc.description.abstractAlarmins are a heterogeneous group of endogenous molecules that signal cellular damage when sensed extracellularly. Heme is an endogenous molecule that acts as a prosthetic group of hemoproteins, such as hemoglobin and myoglobin. When released from damaged red blood cells or muscle cells, oxidized hemoglobin and myoglobin release their prosthetic heme groups, respectively. This generates labile heme, which is sensed by pattern recognition receptors (PRR) expressed by innate immune cells and possibly regulatory T cells (TREG). The ensuing adaptive response, which alerts for the occurrence of red blood cell or muscle cell damage, regulates the pathologic outcome of hemolysis or rhabdomyolysis, respectively. In conclusion, we propose that labile heme is an alarmin.pt_PT
dc.description.sponsorshipFundação para a Ciência e Tecnologia grants: (PTDC/SAU TOX/116627/2010, HMSP-ICT/0022/2010, RECI/IMI-IMU/0038/2012); Fundação de Amparo a Pesquisa do Estado do Rio de Janeiro; Conselho Nacional de Pesquisa, INCTDengue, Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationMiguel P Soares, Marcelo T Bozza, Red alert: labile heme is an alarmin, Current Opinion in Immunology, Volume 38, 2016, Pages 94-100, ISSN 0952-7915, http://dx.doi.org/10.1016/j.coi.2015.11.006. (http://www.sciencedirect.com/science/article/pii/S0952791515001636)pt_PT
dc.identifier.doi10.1016/j.coi.2015.11.006pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/769
dc.language.isoengpt_PT
dc.peerreviewednopt_PT
dc.publisherElsevierpt_PT
dc.relationFCT HMSP-ICT/0022/2010pt_PT
dc.relationTissue Damage Control Regulates The Pathogenesis of Immune Mediated Inflammatory Diseases
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0952791515001636?via%3Dihubpt_PT
dc.subjectAdaptive Immunitypt_PT
dc.subjectAlarminspt_PT
dc.subjectAnimalspt_PT
dc.subjectEndothelial Cellspt_PT
dc.subjectErythrocytespt_PT
dc.subjectGene Expression Regulationpt_PT
dc.subjectHemept_PT
dc.subjectHumanspt_PT
dc.subjectMacrophagespt_PT
dc.subjectMuscle Cellspt_PT
dc.subjectNeutrophilspt_PT
dc.subjectReactive Oxygen Speciespt_PT
dc.subjectReceptors, Pattern Recognitionpt_PT
dc.subjectSignal Transductionpt_PT
dc.subjectImmunity, Innatept_PT
dc.titleRed alert: labile heme is an alarminpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleTissue Damage Control Regulates The Pathogenesis of Immune Mediated Inflammatory Diseases
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-TOX%2F116627%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/RECI%2FIMI-IMU%2F0038%2F2012/PT
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/294709/EU
oaire.citation.endPage100pt_PT
oaire.citation.startPage94pt_PT
oaire.citation.titleCurrent Opinion in Immunologypt_PT
oaire.citation.volume38pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
oaire.fundingStreamFP7
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameEuropean Commission
rcaap.embargofctThis uploaded article has 24 months of embargo period in terms of access, because of the journal's policies and the publisher's copyright policy, which require a period of embargo between 12 months and 48 months.pt_PT
rcaap.rightsembargoedAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication72d8fa6f-1215-4a61-bc70-515eef334d45
relation.isProjectOfPublication1470c3e4-1d23-40cc-9500-9f8843b0e35d
relation.isProjectOfPublication370f9aad-c4ef-4e35-b754-edc840dc6b5e
relation.isProjectOfPublication.latestForDiscovery370f9aad-c4ef-4e35-b754-edc840dc6b5e

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