Evolution of clonal populations approaching a fitness peak

Gordo, I.; Campos, P. R. A.

Publication

Evolution of clonal populations approaching a fitness peak

2013-02-23Journal article

dc.contributor.author	Gordo, I.
dc.contributor.author	Campos, P. R. A.
dc.date.accessioned	2015-12-21T18:25:59Z
dc.date.available	2015-12-21T18:25:59Z
dc.date.issued	2013-02-23
dc.description.abstract	Populations facing novel environments are expected to evolve through the accumulation of adaptive substitutions. The dynamics of adaptation depend on the fitness landscape and possibly on the genetic background on which new mutations arise. Here, we model the dynamics of adaptive evolution at the phenotypic and genotypic levels, focusing on a Fisherian landscape characterized by a single peak. We find that Fisher's geometrical model of adaptation, extended to allow for small random environmental variations, is able to explain several features made recently in experimentally evolved populations. Consistent with data on populations evolving under controlled conditions, the model predicts that mean population fitness increases rapidly when populations face novel environments and then achieves a dynamic plateau, the rate of molecular evolution is remarkably constant over long periods of evolution, mutators are expected to invade and patterns of epistasis vary along the adaptive walk. Negative epistasis is expected in the initial steps of adaptation but not at later steps, a prediction that remains to be tested. Furthermore, populations are expected to exhibit high levels of phenotypic diversity at all times during their evolution. This implies that populations are possibly able to adapt rapidly to novel abiotic environments.	pt_PT
dc.description.sponsorship	CAPES-IGC.	pt_PT
dc.identifier.citation	Gordo I, Campos PRA. 2012 Evolution of clonal populations approaching a fitness peak. Biol Lett 9: 20120239. http://dx.doi.org/10.1098/rsbl.2012.0239	pt_PT
dc.identifier.doi	10.1098/rsbl.2012.0239	pt_PT
dc.identifier.uri	http://hdl.handle.net/10400.7/540
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	The Royal Society	pt_PT
dc.relation	Microbial adaptation within ecosystems
dc.relation.publisherversion	http://rsbl.royalsocietypublishing.org/content/9/1/20120239.long	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	pt_PT
dc.subject	experimental evolution	pt_PT
dc.subject	clonal interference	pt_PT
dc.subject	molecular clock	pt_PT
dc.subject	epistasis	pt_PT
dc.subject	fitness peak	pt_PT
dc.title	Evolution of clonal populations approaching a fitness peak	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.awardTitle	Microbial adaptation within ecosystems
oaire.awardURI	info:eu-repo/grantAgreement/EC/FP7/260421/EU
oaire.citation.endPage	4	pt_PT
oaire.citation.issue	1	pt_PT
oaire.citation.startPage	1	pt_PT
oaire.citation.title	Biology Letters	pt_PT
oaire.citation.volume	9	pt_PT
oaire.fundingStream	FP7
project.funder.identifier	http://doi.org/10.13039/501100008530
project.funder.name	European Commission
rcaap.rights	openAccess	pt_PT
rcaap.type	article	pt_PT
relation.isProjectOfPublication	1f01df05-f8af-4e76-8dec-0fc6237b41fd
relation.isProjectOfPublication.latestForDiscovery	1f01df05-f8af-4e76-8dec-0fc6237b41fd