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The developmental control of size in insects

2014-02Journal article Open access
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dc.contributor.authorNijhout, H. Frederik
dc.contributor.authorRiddiford, Lynn M.
dc.contributor.authorMirth, Christen
dc.contributor.authorShingleton, Alexander W.
dc.contributor.authorSuzuki, Yuichiro
dc.contributor.authorCallier, Viviane
dc.date.accessioned2016-05-12T11:30:58Z
dc.date.available2016-05-12T11:30:58Z
dc.date.issued2014-02
dc.description.abstractThe mechanisms that control the sizes of a body and its many parts remain among the great puzzles in developmental biology. Why do animals grow to a species-specific body size, and how is the relative growth of their body parts controlled to so they grow to the right size, and in the correct proportion with body size, giving an animal its species-characteristic shape? Control of size must involve mechanisms that somehow assess some aspect of size and are upstream of mechanisms that regulate growth. These mechanisms are now beginning to be understood in the insects, in particular in Manduca sexta and Drosophila melanogaster. The control of size requires control of the rate of growth and control of the cessation of growth. Growth is controlled by genetic and environmental factors. Insulin and ecdysone, their receptors, and intracellular signaling pathways are the principal genetic regulators of growth. The secretion of these growth hormones, in turn, is controlled by complex interactions of other endocrine and molecular mechanisms, by environmental factors such as nutrition, and by the physiological mechanisms that sense body size. Although the general mechanisms of growth regulation appear to be widely shared, the mechanisms that regulate final size can be quite diverse.pt_PT
dc.identifier.citationNijhout, H. F., Riddiford, L. M., Mirth, C., Shingleton, A. W., Suzuki, Y. and Callier, V. (2014), The developmental control of size in insects. WIREs Dev Biol, 3: 113–134. doi: 10.1002/wdev.124pt_PT
dc.identifier.doi10.1002/wdev.124pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/602
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherJohn Wiley & Sonspt_PT
dc.relationNão tem financiadores ou patrocionadores indicados no documento.pt_PT
dc.relation.publisherversionhttp://onlinelibrary.wiley.com/doi/10.1002/wdev.124/fullpt_PT
dc.subjectAnimalspt_PT
dc.subjectBody Sizept_PT
dc.subjectDrosophila melanogasterpt_PT
dc.subjectEcdysonept_PT
dc.subjectInsulinpt_PT
dc.subjectLarvapt_PT
dc.subjectManducapt_PT
dc.subjectSignal Transductionpt_PT
dc.titleThe developmental control of size in insectspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage134pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage113pt_PT
oaire.citation.titleWiley Interdisciplinary Reviews: Developmental Biologypt_PT
oaire.citation.volume3pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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