Local Negative Circuits and Cyclic Attractors in Boolean Networks with at most Five Components

Tonello, Elisa; Farcot, Etienne; Chaouiya, Claudine

http://hdl.handle.net/10400.7/932

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Authors

Tonello, Elisa

Farcot, Etienne

Chaouiya, Claudine

Abstract(s)

We consider the following question on the relationship between the asymptotic behaviors of asynchronous dynamics of Boolean networks and their regulatory structures: Does the presence of a cyclic attractor imply the existence of a local negative circuit in the regulatory graph? When the number of model components n verifies n ≥ 6, the answer is known to be negative. We show that the question can be translated into a Boolean satisfiability problem on n ∙ 2^n variables. A Boolean formula expressing the absence of local negative circuits and a necessary condition for the existence of cyclic attractors is found to be unsatisfiable for n ≤ 5. In other words, for Boolean networks with up to 5 components, the presence of a cyclic attractor requires the existence of a local negative circuit.

Keywords

Boolean network, regulatory graph, local negative circuits, cyclic attractors, asynchronous dynamics

URI

http://hdl.handle.net/10400.7/932

Citation

Local Negative Circuits and Cyclic Attractors in Boolean Networks with at most Five Components Elisa Tonello, Etienne Farcot, and Claudine Chaouiya SIAM Journal on Applied Dynamical Systems 2019 18:1, 68-79