dc.contributor.author	Koyama, Takashi
dc.contributor.author	Rodrigues, Marisa A
dc.contributor.author	Athanasiadis, Alekos
dc.contributor.author	Shingleton, Alexander W
dc.contributor.author	Mirth, Christen K
dc.date.accessioned	2016-05-05T10:42:53Z
dc.date.available	2016-05-05T10:42:53Z
dc.date.issued	2014-11-25
dc.description.abstract	Despite their fundamental importance for body size regulation, the mechanisms that stop growth are poorly understood. In Drosophila melanogaster, growth ceases in response to a peak of the molting hormone ecdysone that coincides with a nutrition-dependent checkpoint, critical weight. Previous studies indicate that insulin/insulin-like growth factor signaling (IIS)/Target of Rapamycin (TOR) signaling in the prothoracic glands (PGs) regulates ecdysone biosynthesis and critical weight. Here we elucidate a mechanism through which this occurs. We show that Forkhead Box class O (FoxO), a negative regulator of IIS/TOR, directly interacts with Ultraspiracle (Usp), part of the ecdysone receptor. While overexpressing FoxO in the PGs delays ecdysone biosynthesis and critical weight, disrupting FoxO-Usp binding reduces these delays. Further, feeding ecdysone to larvae eliminates the effects of critical weight. Thus, nutrition controls ecdysone biosynthesis partially via FoxO-Usp prior to critical weight, ensuring that growth only stops once larvae have achieved a target nutritional status.	pt_PT
dc.description.sponsorship	Fundação Calouste Gulbenkian; FCT fellowship: (SFRH/BPD/74313/2010).	pt_PT
dc.identifier.citation	eLife 2014;3:e03091	pt_PT
dc.identifier.doi	10.7554/eLife.03091	pt_PT
dc.identifier.uri	http://hdl.handle.net/10400.7/599
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	Elife Sciences Publications	pt_PT
dc.relation.publisherversion	http://elifesciences.org/content/3/e03091/article-info#api_box	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	pt_PT
dc.subject	D. melanogaster	pt_PT
dc.subject	body size	pt_PT
dc.subject	critical weight	pt_PT
dc.subject	developmental biology	pt_PT
dc.subject	ecdysone	pt_PT
dc.subject	insulin/insulin-like growth factor	pt_PT
dc.subject	nutrition-dependent signaling	pt_PT
dc.subject	stem cells	pt_PT
dc.subject	target of rapamycin	pt_PT
dc.title	Nutritional control of body size through FoxO-Ultraspiracle mediated ecdysone biosynthesis	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.citation.endPage	20	pt_PT
oaire.citation.startPage	1	pt_PT
oaire.citation.title	eLIFE	pt_PT
oaire.citation.volume	3	pt_PT
rcaap.rights	openAccess	pt_PT
rcaap.type	article	pt_PT

Nutritional control of body size through FoxO-Ultraspiracle mediated ecdysone biosynthesis

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