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The Ypt/Rab family and the evolution of trafficking in Fungi
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Resumo(s)
The evolution of the eukaryotic endomembrane system
and the transport pathways of their vesicular intermediates
are poorly understood. A common set of organelles
and pathways seems to be present in all free-living
eukaryotes, but different branches of the tree of life have
a variety of diverse, specialized organelles. Rab/Ypt
proteins are small guanosine triphosphatases with
tissue-specific and organelle-specific localization that
emerged as markers for organelle diversity. Here, I characterize
the Rab/Ypt family in the kingdom Fungi, a sister
kingdom of Animals. I identify and annotate these proteins
in 26 genomes representing near one billion years of
evolution, multiple lifestyles and cellular types. Surprisingly,
the minimal set of Rab/Ypt present in fungi is
similar to, perhaps smaller than, the predicted eukaryotic
ancestral set. This suggests that the saprophytic fungal
lifestyle, multicellularity as well as the highly polarized
secretion associated with hyphal growth did not require
any major innovation in the molecular machinery that
regulates protein trafficking. The Rab/Ypt and other protein
traffic-related families are kept small, not paralleling
increases in genome size, in contrast to the expansion of
such components observed in other branches of the tree
of life, such as the animal and plant kingdoms. This
analysis suggests that multicellularity and cellular diversity
in fungi followed different routes from those followed
by plants and metazoa
Descrição
Palavras-chave
Fungal Proteins/genetics/metabolism Fungi/classification/metabolism Rab GTP-Binding Proteins/genetics/metabolism Evolution Fungi Protein traffic Rab GTPases
Contexto Educativo
Citação
Pereira-Leal, JB (2008) The Ypt/Rab family and the evolution of trafficking in Fungi Traffic. 9: 27-38