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A Three-Dimensional Stereotaxic MRI Brain Atlas of the Cichlid Fish Oreochromis mossambicus

2012-09-11Journal article Open access
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dc.contributor.authorSimões, José M.
dc.contributor.authorTeles, Magda C.
dc.contributor.authorOliveira, Rui F.
dc.contributor.authorVan der Linden, Annemie
dc.contributor.authorVerhoye, Marleen
dc.date.accessioned2016-06-16T15:54:35Z
dc.date.available2016-06-16T15:54:35Z
dc.date.issued2012-09-11
dc.description.abstractThe African cichlid Oreochromis mossambicus (Mozambique tilapia) has been used as a model system in a wide range of behavioural and neurobiological studies. The increasing number of genetic tools available for this species, together with the emerging interest in its use for neurobiological studies, increased the need for an accurate hodological mapping of the tilapia brain to supplement the available histological data. The goal of our study was to elaborate a three-dimensional, high-resolution digital atlas using magnetic resonance imaging, supported by Nissl staining. Resulting images were viewed and analysed in all orientations (transverse, sagittal, and horizontal) and manually labelled to reveal structures in the olfactory bulb, telencephalon, diencephalon, optic tectum, and cerebellum. This high resolution tilapia brain atlas is expected to become a very useful tool for neuroscientists using this fish model and will certainly expand their use in future studies regarding the central nervous system.pt_PT
dc.description.sponsorshipFundação para a Ciência e a Tecnologia grant: (PTDC/PSI/71811/2006); FCT PhD fellowships: (SFRH/BD/40976/2007, SFRH/BD/44848/2008); Plurianual Programme R&D: (unit MAR-LVT-Lisboa-331).pt_PT
dc.identifier.citationSimo ̃ es JM, Teles MC, Oliveira RF, Van der Linden A, Verhoye M (2012) A Three-Dimensional Stereotaxic MRI Brain Atlas of the Cichlid Fish Oreochromis mossambicus . PLoS ONE 7(9): e44086. doi:10.1371/journal.pone.0044086pt_PT
dc.identifier.doi10.1371/journal.pone.0044086pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/651
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPLOSpt_PT
dc.relation.publisherversionhttp://journals.plos.org/plosone/article?id=10.1371/journal.pone.0044086pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnimalspt_PT
dc.subjectBrainpt_PT
dc.subjectBrain Mappingpt_PT
dc.subjectImaging, Three-Dimensionalpt_PT
dc.subjectMagnetic Resonance Imagingpt_PT
dc.subjectStaining and Labelingpt_PT
dc.subjectTilapiapt_PT
dc.subjectTomography, X-Ray Computedpt_PT
dc.subjectAnatomy, Artisticpt_PT
dc.subjectAtlases as Topicpt_PT
dc.subjectStereotaxic Techniquespt_PT
dc.titleA Three-Dimensional Stereotaxic MRI Brain Atlas of the Cichlid Fish Oreochromis mossambicuspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage8pt_PT
oaire.citation.issue9pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titlePLoS ONEpt_PT
oaire.citation.volume7pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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