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The evolution of metazoan α-carbonic anhydrases and their roles in calcium carbonate biomineralization

2014-10-17Journal article Open access
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dc.contributor.authorLe Roy, Nathalie
dc.contributor.authorJackson, Daniel J
dc.contributor.authorMarie, Benjamin
dc.contributor.authorRamos-Silva, Paula
dc.contributor.authorMarin, Frédéric
dc.date.accessioned2015-10-08T10:42:17Z
dc.date.available2015-10-08T10:42:17Z
dc.date.issued2014-10-17
dc.description.abstractThe carbonic anhydrase (CA; EC 4.2.1.1) superfamily is a class of ubiquitous metallo-enzymes that catalyse the reversible hydration of carbon dioxide. The ?-CA family, present in all metazoan clades, is a key enzyme involved in a wide range of physiological functions including pH regulation, respiration, photosynthesis, and biocalcification. This paper reviews the evolution of the ?-CA family, with an emphasis on metazoan ?-CA members involved in biocalcification. Phylogenetic analyses reveal a complex evolutionary history of ?-CAs, and suggest ?-CA was independently co-opted into a variety of skeleton forming roles (e.g. as a provider of HCO3? ions, a structural protein, a nucleation activator, etc.) in multiple metazoan lineages. This evolutionary history is most likely the result of multiple gene duplications coupled with the insertion of repetitive or non-repetitive low-complexity domains (RLCDs/LCDs). These domains, of largely unknown function, appear to be lineage-specific, and provide further support for the hypothesis of independent recruitment of ?-CAs to diverse metazoan biocalcification processes. An analysis of ?-CA sequences associated with biocalcification processes indicates that the domains involved in the activity and conformation of the active site are extremely conserved among metazoans.pt_PT
dc.description.sponsorshipPhD Fellowship from the Ministère de l' Education Nationale et de la Recherche (contract number 27264–2007), ANR project (ACCRO-Earth, ref. BLAN06-2_159971, coordinator Gilles Ramstein, LSCE, Gif/Yvette, France) for years 2007–2011, SU (INTERRVIE project year 2010), COST network TD0903 "Biomineralix", ECTS (internship grant, 2012).pt_PT
dc.identifier10.1186/s12983-014-0075-8
dc.identifier.citationLe Roy et al. : The evolution of metazoan α -carbonic anhydrases and their roles in calcium carbonate biomineralization. Frontiers in Zoology 2014 11 :75.pt_PT
dc.identifier.doi10.1186/s12983-014-0075-8
dc.identifier.urihttp://hdl.handle.net/10400.7/386
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherBioMed Centralpt_PT
dc.relation.publisherversionhttp://www.frontiersinzoology.com/content/11/1/75pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectα -Carbonic anhydrasept_PT
dc.subjectMetazoapt_PT
dc.subjectBiocalcificationpt_PT
dc.subjectBiomineralizationpt_PT
dc.subjectMolecular evolutionpt_PT
dc.subjectLow complexity domains (LCDs)pt_PT
dc.subjectRepetitive low complexity domains (RLCDs)pt_PT
dc.titleThe evolution of metazoan α-carbonic anhydrases and their roles in calcium carbonate biomineralizationpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage16pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleFrontiers in Zoologypt_PT
oaire.citation.volume11pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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