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Tail Bud Progenitor Activity Relies on a Network Comprising Gdf11, Lin28, and Hox13 Genes

2019Journal article Open access
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dc.contributor.authorAires, Rita
dc.contributor.authorde Lemos, Luisa
dc.contributor.authorNóvoa, Ana
dc.contributor.authorJurberg, Arnon Dias
dc.contributor.authorMascrez, Bénédicte
dc.contributor.authorDuboule, Denis
dc.contributor.authorMallo, Moisés
dc.date.accessioned2019-08-29T10:48:27Z
dc.date.available2019-08-29T10:48:27Z
dc.date.issued2019
dc.description.abstractDuring the trunk-to-tail transition, axial progenitors relocate from the epiblast to the tail bud. Here, we show that this process entails a major regulatory switch, bringing tail bud progenitors under Gdf11 signaling control. Gdf11 mutant embryos have an increased number of such progenitors that favor neural differentiation routes, resulting in a dramatic expansion of the neural tube. Moreover, inhibition of Gdf11 signaling recovers the proliferation ability of these progenitors when cultured in vitro. Tail bud progenitor growth is independent of Oct4, relying instead on Lin28 activity. Gdf11 signaling eventually activates Hox genes of paralog group 13, which halt expansion of these progenitors, at least in part, by down-regulating Lin28 genes. Our results uncover a genetic network involving Gdf11, Lin28, and Hox13 genes controlling axial progenitor activity in the tail bud.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.doi10.1016/j.devcel.2018.12.004pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/906
dc.language.isoengpt_PT
dc.relationSCML-MC-60-2014
dc.subjectAnimalspt_PT
dc.subjectBone Morphogenetic Proteinspt_PT
dc.subjectGene Regulatory Networkspt_PT
dc.subjectGrowth Differentiation Factorspt_PT
dc.subjectHomeodomain Proteinspt_PT
dc.subjectMesodermpt_PT
dc.subjectMicept_PT
dc.subjectRNA-Binding Proteinspt_PT
dc.subjectSignal Transductionpt_PT
dc.subjectStem Cellspt_PT
dc.subjectTailpt_PT
dc.subjectGene Expression Regulation, Developmentalpt_PT
dc.titleTail Bud Progenitor Activity Relies on a Network Comprising Gdf11, Lin28, and Hox13 Genespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBEX-BID%2F0899%2F2014/PT
oaire.citation.endPage395.e8pt_PT
oaire.citation.issue3pt_PT
oaire.citation.startPage383pt_PT
oaire.citation.volume48pt_PT
oaire.fundingStream3599-PPCDT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication1aa95bd5-02a2-43c2-bd5f-8bd78d049780
relation.isProjectOfPublication.latestForDiscovery1aa95bd5-02a2-43c2-bd5f-8bd78d049780

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