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Approaches and Perspectives for Development of African Swine Fever Virus Vaccines

2017-10-07Journal article Open access
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dc.contributor.authorArias, Marisa
dc.contributor.authorde la Torre, Ana
dc.contributor.authorDixon, Linda
dc.contributor.authorGallardo, Carmina
dc.contributor.authorJori, Ferran
dc.contributor.authorLaddomada, Alberto
dc.contributor.authorMartins, Carlos
dc.contributor.authorParkhouse, R. Michael
dc.contributor.authorRevilla, Yolanda
dc.contributor.authorRodriguez, Fernando and Jose-Manuel
dc.contributor.authorSanchez-Vizcaino, null
dc.date.accessioned2017-10-23T16:05:18Z
dc.date.available2017-10-23T16:05:18Z
dc.date.issued2017-10-07
dc.descriptionThere is no public supplementary material available. There is no public supplementary material available.pt_PT
dc.description.abstractAfrican swine fever (ASF) is a complex disease of swine, caused by a large DNA virus belonging to the family Asfarviridae. The disease shows variable clinical signs, with high case fatality rates, up to 100%, in the acute forms. ASF is currently present in Africa and Europe where it circulates in different scenarios causing a high socio-economic impact. In most affected regions, control has not been effective in part due to lack of a vaccine. The availability of an effective and safe ASFV vaccines would support and enforce control-eradication strategies. Therefore, work leading to the rational development of protective ASF vaccines is a high priority. Several factors have hindered vaccine development, including the complexity of the ASF virus particle and the large number of proteins encoded by its genome. Many of these virus proteins inhibit the host's immune system thus facilitating virus replication and persistence. We review previous work aimed at understanding ASFV-host interactions, including mechanisms of protective immunity, and approaches for vaccine development. These include live attenuated vaccines, and "subunit" vaccines, based on DNA, proteins, or virus vectors. In the shorter to medium term, live attenuated vaccines are the most promising and best positioned candidates. Gaps and future research directions are evaluated.pt_PT
dc.description.sponsorshipEuropean Commision Directorate-General SANTE "Health and Food Safety"; European Union Reference Laboratory Grant 2016–2017.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationArias, M.; de la Torre, A.; Dixon, L.; Gallardo, C.; Jori, F.; Laddomada, A.; Martins, C.; Parkhouse, R.M.; Revilla, Y.; Rodriguez, F.-M.; Sanchez-Vizcaino. Approaches and Perspectives for Development of African Swine Fever Virus Vaccines. Vaccines 2017, 5, 35.pt_PT
dc.identifier.doi10.3390/vaccines5040035pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/792
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherMDPIpt_PT
dc.relationEuropean Commision Directorate-General SANTEpt_PT
dc.relationEuropean Union Reference Laboratory Grant 2016–2017pt_PT
dc.relation.publisherversionhttp://www.mdpi.com/2076-393X/5/4/35pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAfrican swine feverpt_PT
dc.subjectvaccinept_PT
dc.subjectimmunologypt_PT
dc.subjectvaccine gapspt_PT
dc.titleApproaches and Perspectives for Development of African Swine Fever Virus Vaccinespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage20pt_PT
oaire.citation.issue4pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleVaccinespt_PT
oaire.citation.volume5pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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