On the physiological significance of alternative splicing events in higher plants

Carvalho, Raquel F.; Feijão, Carolina V.; Duque, Paula

Publication

On the physiological significance of alternative splicing events in higher plants

2013-06Journal article

dc.contributor.author	Carvalho, Raquel F.
dc.contributor.author	Feijão, Carolina V.
dc.contributor.author	Duque, Paula
dc.date.accessioned	2016-04-26T16:16:26Z
dc.date.available	2016-04-26T16:16:26Z
dc.date.issued	2013-06
dc.description.abstract	Alternative splicing, which generates multiple transcripts from the same gene and potentially different protein isoforms, is a key posttranscriptional regulatory mechanism for expanding proteomic diversity and functional complexity in higher eukaryotes. The most recent estimates, based on whole transcriptome sequencing, indicate that about 95 % of human and 60 % of Arabidopsis multi-exon genes undergo alternative splicing, suggesting important roles for this mechanism in biological processes. However, while the misregulation of alternative splicing has been associated with many human diseases, its biological relevance in plant systems is just beginning to unfold. We review here the few plant genes for which the production of multiple splice isoforms has been reported to have a clear in vivo functional impact. These case studies implicate alternative splicing in the control of a wide range of physiological and developmental processes, including photosynthetic and starch metabolism, hormone signaling, seed germination, root growth and flowering, as well as in biotic and abiotic stress responses. Future functional characterization of alternative splicing events and identification of the transcripts targeted by major regulators of this versatile means of modulating gene expression should uncover the breadth of its physiological significance in higher plants.	pt_PT
dc.description.sponsorship	FCT fellowship: (SFRH/BPD/80073/2011); Programa Ciência (QREN/MCTES).	pt_PT
dc.identifier.citation	Carvalho, R. F., Feijão, C. V., Duque, P. (2012). On the physiological significance of alternative splicing events in higher plants. Protoplasma, 250(3), 639–650.	pt_PT
dc.identifier.doi	10.1007/s00709-012-0448-9	pt_PT
dc.identifier.uri	http://hdl.handle.net/10400.7/585
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	Springer Verlag	pt_PT
dc.relation	Molecular characterization of a novel RNA-binding protein conferring salt and drought tolerance during seed germination
dc.relation.publisherversion	http://link.springer.com/article/10.1007%2Fs00709-012-0448-9	pt_PT
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/	pt_PT
dc.subject	Alternative splicing	pt_PT
dc.subject	Gene expression	pt_PT
dc.subject	Plant physiology and development	pt_PT
dc.subject	Precursor mRNA	pt_PT
dc.subject	Splice isoforms	pt_PT
dc.title	On the physiological significance of alternative splicing events in higher plants	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.awardTitle	Molecular characterization of a novel RNA-binding protein conferring salt and drought tolerance during seed germination
oaire.awardURI	info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FAGR-PRO%2F119058%2F2010/PT
oaire.citation.endPage	29	pt_PT
oaire.citation.issue	3	pt_PT
oaire.citation.startPage	1	pt_PT
oaire.citation.title	Protoplasma	pt_PT
oaire.citation.volume	250	pt_PT
oaire.fundingStream	3599-PPCDT
project.funder.identifier	http://doi.org/10.13039/501100001871
project.funder.name	Fundação para a Ciência e a Tecnologia
rcaap.rights	openAccess	pt_PT
rcaap.type	article	pt_PT
relation.isProjectOfPublication	53012bcc-50c1-4e9f-a7c7-849eff26ee14
relation.isProjectOfPublication.latestForDiscovery	53012bcc-50c1-4e9f-a7c7-849eff26ee14