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Muller’s ratchet and the pattern of variation at a neutral locus

2002-06Journal article Open access
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dc.contributor.authorGordo, I.
dc.contributor.authorNavarro, A.
dc.contributor.authorCharlesworth, B.
dc.date.accessioned2010-03-31T08:59:55Z
dc.date.available2010-03-31T08:59:55Z
dc.date.issued2002-06
dc.descriptionFor access the publication please visit the following link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1462134/pt_PT
dc.description.abstractThe levels and patterns of variation at a neutral locus are analyzed in a haploid asexual population Undergoing accumulation of deleterious mutations due to Muller's ratchet. We find that the movement Of Muller's ratchet can be associated with a considerable reduction in genetic diversity below classical neutral expectation. The extent to which variability is reduced is a function Of the deleterious initiation rate, the fitness effects of the Imitations, and the population size. Approximate analytical expressions for the expected genetic diversity are compared with simulation results under two different models of deleterious imitations: a model where all deleterious imitations have equal effects and a model where there are two classes of deleterious imitations. We also find that Muller's ratchet can produce a considerable distortion in the neutral frequency spectrum toward an excess of rare variants.pt
dc.identifier.citationGordo, I., A. Navarro and B. Charlesworth (2002) Muller's ratchet and the pattern of variation at a neutral locus. Genetics 161: 835-848pt
dc.identifier.issn0016-6731
dc.identifier.urihttp://hdl.handle.net/10400.7/96
dc.language.isoengpt
dc.relation.publisherversionhttp://www.genetics.org/content/161/2/835.longpt_PT
dc.subjectBACKGROUND SELECTIONpt
dc.subjectASEXUAL POPULATIONSpt
dc.subjectSTATISTICAL TESTSpt
dc.subjectY-CHROMOSOMESpt
dc.subjectDELETERIOUS MUTATIONSpt
dc.subjectDOSAGE COMPENSATIONpt
dc.subjectMOLECULAR EVOLUTIONpt
dc.subjectDNA POLYMORPHISMpt
dc.subjectDEGENERATIONpt
dc.subjectACCUMULATIONpt
dc.titleMuller’s ratchet and the pattern of variation at a neutral locuspt
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage848pt
oaire.citation.startPage835pt
oaire.citation.titleGeneticspt
rcaap.rightsrestrictedAccesspt
rcaap.typearticlept

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