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Host Adaptation Is Contingent upon the Infection Route Taken by Pathogens

2013-09-26Journal article Open access
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dc.contributor.authorMartins, Nelson E.
dc.contributor.authorFaria, Vitor G.
dc.contributor.authorTeixeira, Luis
dc.contributor.authorMagalhães, Sara
dc.contributor.authorSucena, Élio
dc.date.accessioned2015-11-02T16:21:26Z
dc.date.available2015-11-02T16:21:26Z
dc.date.issued2013-09-26
dc.description.abstractEvolution of pathogen virulence is affected by the route of infection. Also, alternate infection routes trigger different physiological responses on hosts, impinging on host adaptation and on its interaction with pathogens. Yet, how route of infection may shape adaptation to pathogens has not received much attention at the experimental level. We addressed this question through the experimental evolution of an outbred Drosophila melanogaster population infected by two different routes (oral and systemic) with Pseudomonas entomophila. The two selection regimes led to markedly different evolutionary trajectories. Adaptation to infection through one route did not protect from infection through the alternate route, indicating distinct genetic bases. Finally, relatively to the control population, evolved flies were not more resistant to bacteria other than Pseudomonas and showed higher susceptibility to viral infections. These specificities and trade-offs may contribute to the maintenance of genetic variation for resistance in natural populations. Our data shows that the infection route affects host adaptation and thus, must be considered in studies of host-pathogen interaction.pt_PT
dc.description.sponsorshipFCT fellowships: (#SFRH/BPD/62964/2009, #SFRH/BD/82299/2011), Instituto Gulbenkian de Ciência/Fundação Calouste Gulbenkian.pt_PT
dc.identifier10.1371/journal.ppat.1003601
dc.identifier.citationMartins NE, Faria VG, Teixeira L, Magalha˜es S, Sucena E´ (2013) Host Adaptation Is Contingent upon the Infection Route Taken by Pathogens. PLoS Pathog 9(9): e1003601. doi:10.1371/journal.ppat.1003601pt_PT
dc.identifier.doi10.1371/journal.ppat.1003601
dc.identifier.urihttp://hdl.handle.net/10400.7/460
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPLOSpt_PT
dc.relationVertical transmission of Wolbachia bacteria in Drosophila
dc.relation.publisherversionhttp://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1003601pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAdaptation, Physiologicalpt_PT
dc.subjectDrosophila melanogasterpt_PT
dc.subjectPseudomonas Infectionspt_PT
dc.subjectImmunity, Innatept_PT
dc.titleHost Adaptation Is Contingent upon the Infection Route Taken by Pathogenspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleVertical transmission of Wolbachia bacteria in Drosophila
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/POCI/POCI%2FBIA-BDE%2F60950%2F2004/PT
oaire.citation.endPage8pt_PT
oaire.citation.issue9pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titlePlos Pathogenspt_PT
oaire.citation.volume9pt_PT
oaire.fundingStreamPOCI
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication14123432-709c-4840-83b6-3289922f79e1
relation.isProjectOfPublication.latestForDiscovery14123432-709c-4840-83b6-3289922f79e1

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