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The regulation of Hox gene expression during animal development

2013-09-17Journal article Open access
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dc.contributor.authorMallo, M.
dc.contributor.authorAlonso, C. R.
dc.date.accessioned2016-06-29T10:37:35Z
dc.date.available2016-06-29T10:37:35Z
dc.date.issued2013-09-17
dc.description.abstractHox genes encode a family of transcriptional regulators that elicit distinct developmental programmes along the head-to-tail axis of animals. The specific regional functions of individual Hox genes largely reflect their restricted expression patterns, the disruption of which can lead to developmental defects and disease. Here, we examine the spectrum of molecular mechanisms controlling Hox gene expression in model vertebrates and invertebrates and find that a diverse range of mechanisms, including nuclear dynamics, RNA processing, microRNA and translational regulation, all concur to control Hox gene outputs. We propose that this complex multi-tiered regulation might contribute to the robustness of Hox expression during development.pt_PT
dc.description.sponsorshipWellcome Trust; Fundação para a Ciência e a Tecnologia grants.pt_PT
dc.identifier.citationThe regulation of Hox gene expression during animal development Moisés Mallo, Claudio R. Alonso Development 2013 140: 3951-3963; doi: 10.1242/dev.068346pt_PT
dc.identifier.doi10.1242/dev.068346pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/672
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherCompany of Biologistspt_PT
dc.relation.publisherversionhttp://dev.biologists.org/content/140/19/3951pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectAnimalspt_PT
dc.subjectChromatinpt_PT
dc.subjectDrosophilapt_PT
dc.subjectDrosophila Proteinspt_PT
dc.subjectGene Expression Regulation, Developmentalpt_PT
dc.subjectGenes, Homeoboxpt_PT
dc.subjectHumanspt_PT
dc.subjectMicept_PT
dc.subjectMicroRNAspt_PT
dc.titleThe regulation of Hox gene expression during animal developmentpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage3963pt_PT
oaire.citation.issue19pt_PT
oaire.citation.startPage3951pt_PT
oaire.citation.titleDevelopmentpt_PT
oaire.citation.volume140pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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