dc.contributor.author	Chelo, Ivo M.
dc.contributor.author	Teotónio, Henrique
dc.date.accessioned	2017-11-22T15:04:34Z
dc.date.available	2017-11-22T15:04:34Z
dc.date.issued	2013-01-04
dc.description	The deposited article is a Post-print version and has been submitted to peer reviewing. This publication hasn't any creative commons license associated. This deposit is composed by the main article plus the supplementary materials of the publication.	pt_PT
dc.description.abstract	The role of balancing selection in maintaining diversity during the evolution of sexual populations to novel environments is poorly understood. To address this issue, we studied the impact of two mating systems, androdioecy and dioecy, on genotype distributions during the experimental evolution of Caenorhabditis elegans. We analyzed the temporal trajectories of 334 single nucleotide polymorphisms, covering 1/3 of the genome, and found extensive allele frequency changes and little loss of heterozygosities after 100 generations. As modeled with numerical simulations, SNP differentiation was consistent with genetic drift and average fitness effects of 2%, assuming that selection acted independently at each locus. Remarkably, inbreeding by self-fertilization was of little consequence to SNP differentiation. Modeling selection on deleterious recessive alleles suggests that the initial evolutionary dynamics can be explained by associative overdominance, but not the later stages because much lower heterozygosities would be maintained during experimental evolution. By contrast, models with selection on true overdominant loci can explain the heterozygote excess observed at all periods, particularly when negative epistasis or independent fitness effects were considered. Overall, these findings indicate that selection at single loci, including purging of recessive alleles, underlies most of the genetic differentiation accomplished during the experiment. Nonetheless, they also imply that maintenance of genetic diversity may in large part be due to balancing selection at multiple loci.	pt_PT
dc.description.sponsorship	European Research Council grant: (stERC/2009-243285).	pt_PT
dc.description.version	info:eu-repo/semantics/publishedVersion	pt_PT
dc.identifier.citation	Chelo, I. M. and Teotónio, H. (2013), THE OPPORTUNITY FOR BALANCING SELECTION IN EXPERIMENTAL POPULATIONS OF CAENORHABDITIS ELEGANS. Evolution, 67: 142–156. doi:10.1111/j.1558-5646.2012.01744.x	pt_PT
dc.identifier.doi	10.1111/j.1558-5646.2012.01744.x	pt_PT
dc.identifier.uri	http://hdl.handle.net/10400.7/810
dc.language.iso	eng	pt_PT
dc.peerreviewed	yes	pt_PT
dc.publisher	Wiley	pt_PT
dc.relation	A study on the interaction among natural selection, mutation and recombination, with Caenorhabditis elegans experimental evolution
dc.relation.publisherversion	http://onlinelibrary.wiley.com/doi/10.1111/j.1558-5646.2012.01744.x/abstract	pt_PT
dc.subject	Adaptation	pt_PT
dc.subject	epistasis	pt_PT
dc.subject	evolutionary genomics	pt_PT
dc.subject	fitness	pt_PT
dc.subject	inbreeding	pt_PT
dc.subject	population structure	pt_PT
dc.title	THE OPPORTUNITY FOR BALANCING SELECTION IN EXPERIMENTAL POPULATIONS OFCAENORHABDITIS ELEGANS	pt_PT
dc.type	journal article
dspace.entity.type	Publication
oaire.awardTitle	A study on the interaction among natural selection, mutation and recombination, with Caenorhabditis elegans experimental evolution
oaire.awardURI	info:eu-repo/grantAgreement/EC/FP7/243285/EU
oaire.citation.endPage	156	pt_PT
oaire.citation.issue	1	pt_PT
oaire.citation.startPage	142	pt_PT
oaire.citation.title	Evolution	pt_PT
oaire.citation.volume	67	pt_PT
oaire.fundingStream	FP7
project.funder.identifier	http://doi.org/10.13039/501100008530
project.funder.name	European Commission
rcaap.rights	openAccess	pt_PT
rcaap.type	article	pt_PT
relation.isProjectOfPublication	f192fb79-7c0d-434b-b3b3-0b3399301ee3
relation.isProjectOfPublication.latestForDiscovery	f192fb79-7c0d-434b-b3b3-0b3399301ee3

THE OPPORTUNITY FOR BALANCING SELECTION IN EXPERIMENTAL POPULATIONS OFCAENORHABDITIS ELEGANS

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