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Short Telomeres in Key Tissues Initiate Local and Systemic Aging in Zebrafish

2016-01-20Journal article Open access
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dc.contributor.authorCarneiro, Madalena C.
dc.contributor.authorHenriques, Catarina M.
dc.contributor.authorNabais, Joana
dc.contributor.authorFerreira, Tânia
dc.contributor.authorCarvalho, Tânia
dc.contributor.authorFerreira, Miguel Godinho
dc.date.accessioned2016-01-25T15:54:20Z
dc.date.available2016-01-25T15:54:20Z
dc.date.issued2016-01-20
dc.description.abstractTelomeres shorten with each cell division and telomere dysfunction is a recognized hallmark of aging. Tissue proliferation is expected to dictate the rate at which telomeres shorten. We set out to test whether proliferative tissues age faster than non-proliferative due to telomere shortening during zebrafish aging. We performed a prospective study linking telomere length to tissue pathology and disease. Contrary to expectations, we show that telomeres shorten to critical lengths only in specific tissues and independently of their proliferation rate. Short telomeres accumulate in the gut but not in other highly proliferative tissues such as the blood and gonads. Notably, the muscle, a low proliferative tissue, accumulates short telomeres and DNA damage at the same rate as the gut. Together, our work shows that telomere shortening and DNA damage in key tissues triggers not only local dysfunction but also anticipates the onset of age-associated diseases in other tissues, including cancer.pt_PT
dc.description.sponsorshipHHMI International Early Career Scientist, FCT fellowships, Howard Hughes Medical Institute grants.pt_PT
dc.identifier.citationCarneiro MC, Henriques CM, Nabais J, Ferreira T, Carvalho T, Ferreira MG (2016) Short Telomeres in Key Tissues Initiate Local and Systemic Aging in Zebrafish. PLoS Genet 12(1): e1005798. doi:10.1371/journal.pgen.1005798pt_PT
dc.identifier.doi10.1371/journal.pgen.1005798pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/549
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherPLOSpt_PT
dc.relation.publisherversionhttp://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1005798pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectTelomerespt_PT
dc.subjectZebrafishpt_PT
dc.subjectAgingpt_PT
dc.subjectKidneyspt_PT
dc.subjectAging and cancerpt_PT
dc.subjectMuscle analysispt_PT
dc.subjectApoptosispt_PT
dc.subjectMuscle tissuept_PT
dc.titleShort Telomeres in Key Tissues Initiate Local and Systemic Aging in Zebrafishpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-ORG%2F116826%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-ONC%2F116821%2F2010/PT
oaire.citation.endPage31pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titlePLOS Geneticspt_PT
oaire.citation.volume12pt_PT
oaire.fundingStream3599-PPCDT
oaire.fundingStream3599-PPCDT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication5235261f-0465-4be9-929e-4cd01288a6fe
relation.isProjectOfPublication322214da-9ed1-436e-a507-eee1118be0b1
relation.isProjectOfPublication.latestForDiscovery5235261f-0465-4be9-929e-4cd01288a6fe

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