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Potential for adaptation overrides cost of resistance

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dc.contributor.authorMoura de Sousa, Jorge
dc.contributor.authorSousa, Ana
dc.contributor.authorBourgard, Catarina
dc.contributor.authorGordo, Isabel
dc.date.accessioned2018-05-18T11:33:32Z
dc.date.available2018-05-18T11:33:32Z
dc.date.issued2015-09
dc.descriptionThe deposited article is a post-print version and has been submitted to peer review.pt_PT
dc.descriptionThis deposit is composed by the main article plus the supplementary materials of the publication.pt_PT
dc.descriptionThis work is licensed under the Creative Commons Attribution-NonCommercial 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/pt_PT
dc.description.abstractTo investigate the cost of antibiotic resistance versus the potential for resistant clones to adapt in maintaining polymorphism for resistance. Materials & methods: Experimental evolution of Escherichia coli carrying different resistance alleles was performed under an environment devoid of antibiotics and evolutionary parameters estimated from their frequencies along time. Results & conclusion: Costly resistance mutations were found to coexist with lower cost resistances for hundreds of generations, contrary to the hypothesis that the cost of a resistance dictates its extinction. Estimated evolutionary parameters for the different resistance backgrounds suggest a higher adaptive potential of clones with costly antibiotic resistance mutations, overriding their initial cost of resistance and allowing their maintenance in the absence of drugs.pt_PT
dc.description.sponsorshipThe research leading to these results has received funding from the European Research Council under the European Community's Seventh Framework Programme (FP7/2007–2013)/ERC grant agreement no 260421 – ECOADAPT, and PTDC/BIA-EVF/114622/2009, financed by Fundação para a Ciência e Tecnologia (FCT). I Gordo acknowledges the salary support of LAO/ITQB & FCT. JM de Sousa acknowledges the scholarship SFRH/BD/89151/2012, from FCT.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationPotential for adaptation overrides cost of resistance Jorge Moura de Sousa, Ana Sousa, Catarina Bourgard, and Isabel Gordo Future Microbiology 2015 10:9, 1415-1431pt_PT
dc.identifier.doi10.2217/fmb.15.61pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/870
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFuture Medicinept_PT
dc.relationMicrobial adaptation within ecosystems
dc.relationEXPLORING ADAPTATION BEYOND FITNESS PEAKS
dc.relation.publisherversionhttps://www.futuremedicine.com/doi/10.2217/fmb.15.61pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectantibiotic resistancept_PT
dc.subjectclonal interferencept_PT
dc.subjectepistasispt_PT
dc.subjectevolvabilitypt_PT
dc.subjectexperimental evolutionpt_PT
dc.titlePotential for adaptation overrides cost of resistancept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleMicrobial adaptation within ecosystems
oaire.awardTitleEXPLORING ADAPTATION BEYOND FITNESS PEAKS
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/260421/EU
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBIA-EVF%2F114622%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBD%2F89151%2F2012/PT
oaire.citation.endPage1431pt_PT
oaire.citation.issue9pt_PT
oaire.citation.startPage1415pt_PT
oaire.citation.titleFuture Microbiologypt_PT
oaire.citation.volume10pt_PT
oaire.fundingStreamFP7
oaire.fundingStream3599-PPCDT
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameEuropean Commission
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication1f01df05-f8af-4e76-8dec-0fc6237b41fd
relation.isProjectOfPublicationd59762ac-c556-4604-9c9f-9fd4126b56d7
relation.isProjectOfPublication85cd72e1-1c33-480c-ae77-f1effb2ee9cc
relation.isProjectOfPublication.latestForDiscovery1f01df05-f8af-4e76-8dec-0fc6237b41fd

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