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Control of Disease Tolerance to Malaria by Nitric Oxide and Carbon Monoxide

2014-07-10Journal article Open access
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dc.contributor.authorJeney, Viktória
dc.contributor.authorRamos, Susana
dc.contributor.authorBergman, Marie-Louise
dc.contributor.authorBechmann, Ingo
dc.contributor.authorTischer, Jasmin
dc.contributor.authorFerreira, Ana
dc.contributor.authorOliveira-Marques, Virginia
dc.contributor.authorJanse, Chris J.
dc.contributor.authorRebelo, Sofia
dc.contributor.authorCardoso, Silvia
dc.contributor.authorSoares, Miguel P.
dc.date.accessioned2015-10-08T09:43:19Z
dc.date.available2015-10-08T09:43:19Z
dc.date.issued2014-07-10
dc.description.abstractNitric oxide (NO) and carbon monoxide (CO) are gasotransmitters that suppress the development of severe forms of malaria associated with Plasmodium infection. Here, we addressed the mechanism underlying their protective effect against experimental cerebral malaria (ECM), a severe form of malaria that develops in Plasmodium-infected mice, which resembles, in many aspects, human cerebral malaria (CM). NO suppresses the pathogenesis of ECM via a mechanism involving (1) the transcription factor nuclear factor erythroid 2-related factor 2 (NRF-2), (2) induction of heme oxygenase-1 (HO-1), and (3) CO production via heme catabolism by HO-1. The protection afforded by NO is associated with inhibition of CD4(+) T helper (TH) and CD8(+) cytotoxic (TC) T cell activation in response to Plasmodium infection via a mechanism involving HO-1 and CO. The protective effect of NO and CO is not associated with modulation of host pathogen load, suggesting that these gasotransmitters establish a crosstalk-conferring disease tolerance to Plasmodium infection.pt_PT
dc.description.sponsorshipInstituto Gulbenkian de Ciência, FCT grants: ( PTDC/SAU-FCF/100762/2008, PTDC/SAU-TOX/116627/2010, HMSP-ICT/0018/2011, RECI-IMI-IMU-0038-2012, AU-MII/65765/2006, AU-MII/65765/2006), European Social Fund TÁMOP-4.2.2.A-11/1/KONV-2012-0045.pt_PT
dc.identifier10.1016/j.celrep.2014.05.054
dc.identifier.doi10.1016/j.celrep.2014.05.054
dc.identifier.urihttp://hdl.handle.net/10400.7/385
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherCell Presspt_PT
dc.relationTissue Damage Control Regulates The Pathogenesis of Immune Mediated Inflammatory Diseases
dc.relationCrosstalk Between Nitric and Carbon Monoxide in Suppressing the Pathogenesis of Cerebral Malaria
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S2211124714004483pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectMalaria Infectionpt_PT
dc.subjectNitric Oxidept_PT
dc.titleControl of Disease Tolerance to Malaria by Nitric Oxide and Carbon Monoxidept_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleTissue Damage Control Regulates The Pathogenesis of Immune Mediated Inflammatory Diseases
oaire.awardTitleCrosstalk Between Nitric and Carbon Monoxide in Suppressing the Pathogenesis of Cerebral Malaria
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/294709/EU
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/220152/EU
oaire.citation.endPage136pt_PT
oaire.citation.issue1pt_PT
oaire.citation.startPage126pt_PT
oaire.citation.titleCell Reportspt_PT
oaire.citation.volume8pt_PT
oaire.fundingStreamFP7
oaire.fundingStreamFP7
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication370f9aad-c4ef-4e35-b754-edc840dc6b5e
relation.isProjectOfPublicationc301de90-72b2-4ebc-a3e7-acdf3d93f77d
relation.isProjectOfPublication.latestForDiscovery370f9aad-c4ef-4e35-b754-edc840dc6b5e

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