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Beyond cellular detoxification: a plethora of physiological roles for MDR transporter homologs in plants

2014-05-30Journal article Open access
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dc.contributor.authorRemy, Estelle
dc.contributor.authorDuque, Paula
dc.date.accessioned2015-10-01T16:04:31Z
dc.date.available2015-10-01T16:04:31Z
dc.date.issued2014-05-30
dc.description.abstractHigher plants possess a multitude of Multiple Drug Resistance (MDR) transporter homologs that group into three distinct and ubiquitous families-the ATP-Binding Cassette (ABC) superfamily, the Major Facilitator Superfamily (MFS), and the Multidrug And Toxic compound Extrusion (MATE) family. As in other organisms, such as fungi, mammals, and bacteria, MDR transporters make a primary contribution to cellular detoxification processes in plants, mainly through the extrusion of toxic compounds from the cell or their sequestration in the central vacuole. This review aims at summarizing the currently available information on the in vivo roles of MDR transporters in plant systems. Taken together, these data clearly indicate that the biological functions of ABC, MFS, and MATE carriers are not restricted to xenobiotic and metal detoxification. Importantly, the activity of plant MDR transporters also mediates biotic stress resistance and is instrumental in numerous physiological processes essential for optimal plant growth and development, including the regulation of ion homeostasis and polar transport of the phytohormone auxin.pt_PT
dc.description.sponsorshipFCT PostDoctoral Fellowship: SFRH/BPD/44640/2008.pt_PT
dc.identifier10.3389/fphys.2014.00201
dc.identifier.citationRemy E and Duque P (2014) Beyond cellular detoxification: a plethora of physiological roles for MDR transporter homologs in plants. Front. Physiol. 5:201. doi: 10.3389/fphys.2014.00201pt_PT
dc.identifier.doi10.3389/fphys.2014.00201
dc.identifier.doi10.3389/fphys.2014.00201
dc.identifier.urihttp://hdl.handle.net/10400.7/337
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherFRONTIERS RESEARCH FOUNDATIONpt_PT
dc.relation.publisherversionhttp://journal.frontiersin.org/article/10.3389/fphys.2014.00201/abstractpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectATP-Binding Cassette (ABC)pt_PT
dc.subjectionhomeostasispt_PT
dc.subjectMajor Facilitator Superfamily (MFS)pt_PT
dc.subjectmembrane transporterpt_PT
dc.subjectMultidrug And Toxin compound Extrusion (MATE)pt_PT
dc.subjectplant systemspt_PT
dc.subjectpolar auxin transport (PAT)pt_PT
dc.subjectxenobiotic detoxificationpt_PT
dc.titleBeyond cellular detoxification: a plethora of physiological roles for MDR transporter homologs in plantspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/EXPL%2FAGR-PRO%2F1013%2F2013/PT
oaire.citation.endPage10pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleFrontiers in Physiologypt_PT
oaire.citation.volume5pt_PT
oaire.fundingStream3599-PPCDT
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.nameFundação para a Ciência e a Tecnologia
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationb66a8488-68e7-452c-a018-223ce17fb469
relation.isProjectOfPublication.latestForDiscoveryb66a8488-68e7-452c-a018-223ce17fb469

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