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Host adaptation to viruses relies on few genes with different cross-resistance properties

2014-04-22Journal article Open access
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dc.contributor.authorMartins, N. E.
dc.contributor.authorFaria, V. G.
dc.contributor.authorNolte, V.
dc.contributor.authorSchlotterer, C.
dc.contributor.authorTeixeira, L.
dc.contributor.authorSucena, E.
dc.contributor.authorMagalhaes, S.
dc.date.accessioned2017-11-06T19:05:28Z
dc.date.available2017-11-06T19:05:28Z
dc.date.issued2014-04-22
dc.descriptionThe deposited article is a post-print version and has peer review. This deposit is composed by the main article, and it hasn't any supplementary materials associated. The supplementary materials of the publication are only present in the editor's page of this article. This publication hasn't any creative commons license associated.pt_PT
dc.description.abstractHost adaptation to one parasite may affect its response to others. However, the genetics of these direct and correlated responses remains poorly studied. The overlap between these responses is instrumental for the understanding of host evolution in multiparasite environments. We determined the genetic and phenotypic changes underlying adaptation of Drosophila melanogaster to Drosophila C virus (DCV). Within 20 generations, flies selected with DCV showed increased survival after DCV infection, but also after cricket paralysis virus (CrPV) and flock house virus (FHV) infection. Whole-genome sequencing identified two regions of significant differentiation among treatments, from which candidate genes were functionally tested with RNAi. Three genes were validated--pastrel, a known DCV-response gene, and two other loci, Ubc-E2H and CG8492. Knockdown of Ubc-E2H and pastrel also led to increased sensitivity to CrPV, whereas knockdown of CG8492 increased susceptibility to FHV infection. Therefore, Drosophila adaptation to DCV relies on few major genes, each with different cross-resistance properties, conferring host resistance to several parasites.pt_PT
dc.description.sponsorshipFundação para a Ciência e a Tecnologia grants: (SFRH/BPD/62964/2009, SFRH/BD/82299/2011, PTDC/SAU-IMU/120673/2010); Austrian Science Fund grants: (P22725, P19467); European Research Council grant: (ArchAdapt); Instituto Gulbenkian de Ciência/Fundação Calouste Gulbenkian; Vetmeduni.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationNelson E. Martins, Vítor G. Faria, Viola Nolte, Christian Schlötterer, Luis Teixeira, Élio Sucena, and Sara Magalhães Host adaptation to viruses relies on few genes with different cross-resistance properties PNAS 2014 111 (16) 5938-5943; published ahead of print April 7, 2014, doi:10.1073/pnas.1400378111pt_PT
dc.identifier.doi10.1073/pnas.1400378111pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/801
dc.language.isoporpt_PT
dc.peerreviewedyespt_PT
dc.publisherNational Academy of Sciencespt_PT
dc.relationP22725pt_PT
dc.relationEVOLUTION OF THE IMMUNE RESPONSE OF DROSOPHILA MELANOGASTER: INSIGHTS USING EXPERIMENTAL EVOLUTION TO MULTIPLE PATHOGENS AND EXPOSURE SCENARIOS
dc.relationThe architecture of adaptation to novel environments
dc.relation.publisherversionhttp://www.pnas.org/content/111/16/5938.abstractpt_PT
dc.subjecthost–parasite interactionspt_PT
dc.subjectexperimental evolutionpt_PT
dc.subjectDrosophila immunitypt_PT
dc.subjectevolve and resequencept_PT
dc.titleHost adaptation to viruses relies on few genes with different cross-resistance propertiespt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleEVOLUTION OF THE IMMUNE RESPONSE OF DROSOPHILA MELANOGASTER: INSIGHTS USING EXPERIMENTAL EVOLUTION TO MULTIPLE PATHOGENS AND EXPOSURE SCENARIOS
oaire.awardTitleThe architecture of adaptation to novel environments
oaire.awardURIinfo:eu-repo/grantAgreement/FCT//SFRH%2FBPD%2F62964%2F2009/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/SFRH/SFRH%2FBD%2F82299%2F2011/PT
oaire.awardURIinfo:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FSAU-IMU%2F120673%2F2010/PT
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/294485/EU
oaire.citation.endPage5943pt_PT
oaire.citation.issue16pt_PT
oaire.citation.startPage5938pt_PT
oaire.citation.titleProceedings of the National Academy of Sciencespt_PT
oaire.citation.volume111pt_PT
oaire.fundingStreamSFRH
oaire.fundingStream3599-PPCDT
oaire.fundingStreamFP7
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100001871
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameFundação para a Ciência e a Tecnologia
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublication41fc5436-eb50-4a62-9c43-d97ef6402690
relation.isProjectOfPublicationac14821e-d799-459e-83a4-da88e7da795d
relation.isProjectOfPublicationf7530847-de62-4783-8008-05a7ccecbbbd
relation.isProjectOfPublication8815d855-e6f3-438e-a201-b559ccd57e0e
relation.isProjectOfPublication.latestForDiscovery8815d855-e6f3-438e-a201-b559ccd57e0e

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