Repository logo
 
Publication

Evolution of mir-92a Underlies Natural Morphological Variation in Drosophila melanogaster

2013-03-18Journal article Open access
Simple item page
dc.contributor.authorArif, Saad
dc.contributor.authorMurat, Sophie
dc.contributor.authorAlmudi, Isabel
dc.contributor.authorNunes, Maria D.S.
dc.contributor.authorBortolamiol-Becet, Diane
dc.contributor.authorMcGregor, Naomi S.
dc.contributor.authorCurrie, James M.S.
dc.contributor.authorHughes, Harri
dc.contributor.authorRonshaugen, Matthew
dc.contributor.authorSucena, Élio
dc.contributor.authorLai, Eric C.
dc.contributor.authorSchlötterer, Christian
dc.contributor.authorMcGregor, Alistair P.
dc.date.accessioned2017-11-07T15:27:13Z
dc.date.available2017-11-07T15:27:13Z
dc.date.issued2013-03-18
dc.descriptionThe deposited article is a post-print version and has peer review. This deposit is composed by the main article, and it hasn't any supplementary materials associated. The supplementary materials are present in the publisher's page in the following link: http://www.sciencedirect.com/science/MiamiMultiMediaURL/1-s2.0-S0960982213001899/1-s2.0-S0960982213001899-mmc1.pdf/272099/html/S0960982213001899/187ecb1b8f94027ceebb87907c58eb3f/mmc1.pdfpt_PT
dc.description.abstractIdentifying the genetic mechanisms underlying phenotypic change is essential to understanding how gene regulatory networks and ultimately the genotype-to-phenotype map evolve. It is recognized that microRNAs (miRNAs) have the potential to facilitate evolutionary change [1-3]; however, there are no known examples of natural morphological variation caused by evolutionary changes in miRNA expression. Therefore, the contribution of miRNAs to evolutionary change remains unknown [1, 4]. Drosophila melanogaster subgroup species display a portion of trichome-free cuticle on the femur of the second leg called the "naked valley." It was previously shown that Ultrabithorax (Ubx) is involved in naked valley variation between D. melanogaster and D. simulans [5, 6]. However, naked valley size also varies among populations of D. melanogaster, ranging from 1,000 up to 30,000 μm(2). We investigated the genetic basis of intraspecific differences in the naked valley in D. melanogaster and found that neither Ubx nor shavenbaby (svb) [7, 8] contributes to this morphological difference. Instead, we show that changes in mir-92a expression underlie the evolution of naked valley size in D. melanogaster through repression of shavenoid (sha) [9]. Therefore, our results reveal a novel mechanism for morphological evolution and suggest that modulation of the expression of miRNAs potentially plays a prominent role in generating organismal diversity.pt_PT
dc.description.sponsorshipAustrian Science Fund (FWF) grant: (M1059-B09); Oxford Brookes University; National Institute of General Medical Sciences of the National Institutes of Health grant: (R01-GM083300).pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationSaad Arif, Sophie Murat, Isabel Almudi, Maria D.S. Nunes, Diane Bortolamiol-Becet, Naomi S. McGregor, James M.S. Currie, Harri Hughes, Matthew Ronshaugen, Élio Sucena, Eric C. Lai, Christian Schlötterer, Alistair P. McGregor, Evolution of mir-92a Underlies Natural Morphological Variation in Drosophila melanogaster, Current Biology, Volume 23, Issue 6, 18 March 2013, Pages 523-528, ISSN 0960-9822, https://doi.org/10.1016/j.cub.2013.02.018. (https://www.sciencedirect.com/science/article/pii/S0960982213001899)pt_PT
dc.identifier.doi10.1016/j.cub.2013.02.018pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/802
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElsevierpt_PT
dc.relationM1059-B09pt_PT
dc.relationR01-GM083300pt_PT
dc.relation.publisherversionhttp://www.sciencedirect.com/science/article/pii/S0960982213001899pt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectAnimalspt_PT
dc.subjectChromosome Mappingpt_PT
dc.subjectDrosophila melanogasterpt_PT
dc.subjectExtremitiespt_PT
dc.subjectFemalept_PT
dc.subjectIn Situ Hybridizationpt_PT
dc.subjectMalept_PT
dc.subjectMicroRNAspt_PT
dc.subjectPupapt_PT
dc.subjectQuantitative Trait Locipt_PT
dc.subjectEvolution, Molecularpt_PT
dc.subjectGene Expression Regulation, Developmentalpt_PT
dc.titleEvolution of mir-92a Underlies Natural Morphological Variation in Drosophila melanogasterpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage528pt_PT
oaire.citation.issue6pt_PT
oaire.citation.startPage523pt_PT
oaire.citation.titleCurrent Biologypt_PT
oaire.citation.volume23pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

Files

Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
McGregor,A.P_(2013)_Curr.Biol_post-print.pdf
Size:
5.81 MB
Format:
Adobe Portable Document Format
Description:
main article
Download
License bundle
Now showing 1 - 1 of 1
No Thumbnail Available
Name:
license.txt
Size:
1.71 KB
Format:
Item-specific license agreed upon to submission
Description:
Download

Collections

ED - Artigos