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Nutritional control of body size through FoxO-Ultraspiracle mediated ecdysone biosynthesis

2014-11-25Journal article Open access
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dc.contributor.authorKoyama, Takashi
dc.contributor.authorRodrigues, Marisa A
dc.contributor.authorAthanasiadis, Alekos
dc.contributor.authorShingleton, Alexander W
dc.contributor.authorMirth, Christen K
dc.date.accessioned2015-11-12T13:06:31Z
dc.date.available2015-11-12T13:06:31Z
dc.date.issued2014-11-25
dc.description.abstractDespite their fundamental importance for body size regulation, the mechanisms that stop growth are poorly understood. In Drosophila melanogaster, growth ceases in response to a peak of the molting hormone ecdysone that coincides with a nutrition-dependent checkpoint, critical weight. Previous studies indicate that insulin/insulin-like growth factor signaling (IIS)/Target of Rapamycin (TOR) signaling in the prothoracic glands (PGs) regulates ecdysone biosynthesis and critical weight. Here we elucidate a mechanism through which this occurs. We show that Forkhead Box class O (FoxO), a negative regulator of IIS/TOR, directly interacts with Ultraspiracle (Usp), part of the ecdysone receptor. While overexpressing FoxO in the PGs delays ecdysone biosynthesis and critical weight, disrupting FoxO-Usp binding reduces these delays. Further, feeding ecdysone to larvae eliminates the effects of critical weight. Thus, nutrition controls ecdysone biosynthesis partially via FoxO-Usp prior to critical weight, ensuring that growth only stops once larvae have achieved a target nutritional status.pt_PT
dc.description.sponsorshipFCT: (SFRH/BPD/74313/2010), Calouste Gulbenkian Foundation.pt_PT
dc.identifier.doi10.7554/eLife.03091pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.7/491
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherElife Sciences Publicationspt_PT
dc.relation.publisherversionhttp://elifesciences.org/content/3/e03091/article-infopt_PT
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/pt_PT
dc.subjectD. melanogasterpt_PT
dc.subjectbody sizept_PT
dc.subjectcritical weightpt_PT
dc.subjectdevelopmental biologypt_PT
dc.subjectecdysonept_PT
dc.subjectinsulin/insulin-like growth factorpt_PT
dc.subjectnutrition-dependent signalingpt_PT
dc.subjectstem cellspt_PT
dc.subjecttarget of rapamycinpt_PT
dc.titleNutritional control of body size through FoxO-Ultraspiracle mediated ecdysone biosynthesispt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage20pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleeLIFEpt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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