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An experimental test on the probability of extinction of new genetic variants

2013-09-13Journal article Open access
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dc.contributor.authorChelo, Ivo M.
dc.contributor.authorNédli, Judit
dc.contributor.authorGordo, Isabel
dc.contributor.authorTeotónio, Henrique
dc.date.accessioned2015-10-26T12:26:58Z
dc.date.available2015-10-26T12:26:58Z
dc.date.issued2013-09-13
dc.description.abstractIn 1927, J.B.S. Haldane reasoned that the probability of fixation of new beneficial alleles is twice their fitness effect. This result, later generalized by M. Kimura, has since become the cornerstone of modern population genetics. There is no experimental test of Haldane's insight that new beneficial alleles are lost with high probability. Here we demonstrate that extinction rates decrease with increasing initial numbers of beneficial alleles, as expected, by performing invasion experiments with inbred lines of the nematode Caenorhabditis elegans. We further show that the extinction rates of deleterious alleles are higher than those of beneficial alleles, also as expected. Interestingly, we also find that for these inbred lines, when at intermediate frequencies, the fate of invaders might not result in their ultimate fixation or loss but on their maintenance. Our study confirms the key results from classical population genetics and highlights that the nature of adaptation can be complex.pt_PT
dc.description.sponsorshipHuman Frontiers Science Program grant: (RGP0045/2010).pt_PT
dc.identifier10.1038/ncomms3417
dc.identifier.citationChelo, I. M. et al. An experimental test on the probability of extinction of new genetic variants. Nat. Commun. 4:2417 doi: 10.1038/ncomms3417 (2013).pt_PT
dc.identifier.doi10.1038/ncomms3417
dc.identifier.urihttp://hdl.handle.net/10400.7/440
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherNature Publishing Grouppt_PT
dc.relationA study on the interaction among natural selection, mutation and recombination, with Caenorhabditis elegans experimental evolution
dc.relation.publisherversionhttp://www.nature.com/ncomms/2013/130913/ncomms3417/full/ncomms3417.htmlpt_PT
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/pt_PT
dc.subjectExtinction, Biologicalpt_PT
dc.subjectGenetic Variationpt_PT
dc.subjectProbabilitypt_PT
dc.titleAn experimental test on the probability of extinction of new genetic variantspt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.awardTitleA study on the interaction among natural selection, mutation and recombination, with Caenorhabditis elegans experimental evolution
oaire.awardURIinfo:eu-repo/grantAgreement/EC/FP7/243285/EU
oaire.citation.endPage8pt_PT
oaire.citation.startPage1pt_PT
oaire.citation.titleNature Communicationspt_PT
oaire.citation.volume4pt_PT
oaire.fundingStreamFP7
project.funder.identifierhttp://doi.org/10.13039/501100008530
project.funder.nameEuropean Commission
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT
relation.isProjectOfPublicationf192fb79-7c0d-434b-b3b3-0b3399301ee3
relation.isProjectOfPublication.latestForDiscoveryf192fb79-7c0d-434b-b3b3-0b3399301ee3

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