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Low frequency of CD4(+) CD25(+) Treg in SLE patients: a heritable trait associated with CTLA4 and TGF gene variants

2007-01-27Journal article Open access
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dc.contributor.authorBarreto, M.
dc.contributor.authorFerreira, RC.
dc.contributor.authorLourenço, L.
dc.contributor.authorMoraes-Fontes, MF.
dc.contributor.authorSantos, E.
dc.contributor.authorAlves, M.
dc.contributor.authorCarvalho, C.
dc.contributor.authorMartins, B.
dc.contributor.authorAndreia, R.
dc.contributor.authorViana, JF.
dc.contributor.authorVasconcelos, C.
dc.contributor.authorMota-Vieira, L.
dc.contributor.authorFerreira, C.
dc.contributor.authorDemengeot, J.
dc.contributor.authorVicente, AM.
dc.date.accessioned2010-08-11T11:10:29Z
dc.date.available2010-08-11T11:10:29Z
dc.date.issued2007-01-27
dc.description.abstractBackground: CD4(+)CD25(+) regulatory T cells play an essential role in maintaining immune homeostasis and preventing autoimmunity. Therefore, defects in Treg development, maintenance or function have been associated with several human autoimmune diseases including Systemic Lupus Erythematosus (SLE), a systemic autoimmune disease characterized by loss of tolerance to nuclear components and significantly more frequent in females.pt
dc.identifier.citationBarreto, M., Ferreira, R.C., Lourenco, L., Moraes-Fontes, M.F.,Santos, E., Alves, M.,Carvalho, C., Martins, B., Andreia, R., Viana, J. F., Vasconcelos, C., Mota-Vieira, L., Ferreira, C., Demengeot, J., Vicente, A.M. (2009). “Low frequency of CD4(+)CD25(+) Treg in SLE patients: a heritable trait associated with CTLA4 and TGF gene variants”. BMC Immunology. 10: 1 -14pt
dc.identifier.issn1471-2172
dc.identifier.urihttp://hdl.handle.net/10400.7/160
dc.language.isoengpt
dc.publisherBiomed Centralpt
dc.subjectREGULATORY T-CELLSpt
dc.subjectSYSTEMIC-LUPUS-ERYTHEMATOSUSpt
dc.subjectIMMUNOLOGICAL SELF-TOLERANCEpt
dc.subjectIN-VIVO EXPANSIONpt
dc.subjectAUTOANTIBODY PRODUCTIONpt
dc.subjectMULTIPLE-SCLEROSISpt
dc.titleLow frequency of CD4(+) CD25(+) Treg in SLE patients: a heritable trait associated with CTLA4 and TGF gene variantspt
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage14pt
oaire.citation.startPage1pt
oaire.citation.titleBMC Immunologypt
rcaap.rightsopenAccesspt
rcaap.typearticlept

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