Publication
Regulatory landscape of the Hox transcriptome
| dc.contributor.author | Casaca, Ana | |
| dc.contributor.author | Hauswirth, Gabriel M | |
| dc.contributor.author | Bildsoe, Heidi | |
| dc.contributor.author | Mallo, Moisés | |
| dc.contributor.author | McGlinn, Edwina | |
| dc.date.accessioned | 2019-08-29T10:45:20Z | |
| dc.date.available | 2019-08-29T10:45:20Z | |
| dc.date.issued | 2018 | |
| dc.description.abstract | Precise regulation of Hox gene activity is essential to achieve proper control of animal embryonic development and to avoid generation of a variety of malignancies. This is a multilayered process, including complex polycistronic transcription, RNA processing, microRNA repression, long noncoding RNA regulation and sequence-specific translational control, acting together to achieve robust quantitative and qualitative Hox protein output. For many such mechanisms, the Hox cluster gene network has turned out to serve as a paradigmatic model for their study. In this review, we discuss current knowledge of how the different layers of post-transcriptional regulation and the production of a variety of noncoding RNA species control Hox output, and how this shapes formation of developmental systems that are reproducibly patterned by complex Hox networks. | pt_PT |
| dc.description.sponsorship | Fundação para a Ciência e a Tecnologia grants: ( PTDC/BEX-BID/0899/2014, SFRH/BD/51876/2012); Santa Casa da Misericordia de Lisboa grant: (SCML-MC-60-2014); | pt_PT |
| dc.description.version | info:eu-repo/semantics/publishedVersion | pt_PT |
| dc.identifier.doi | 10.1387/ijdb.180270em | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.7/904 | |
| dc.language.iso | eng | pt_PT |
| dc.relation | SCML-MC-60-2014 | pt_PT |
| dc.subject | Animals | pt_PT |
| dc.subject | Embryonic Development | pt_PT |
| dc.subject | Genes, Homeobox | pt_PT |
| dc.subject | MicroRNAs | pt_PT |
| dc.subject | RNA, Long Noncoding | pt_PT |
| dc.subject | Gene Expression Regulation, Developmental | pt_PT |
| dc.subject | Transcriptome | pt_PT |
| dc.title | Regulatory landscape of the Hox transcriptome | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.awardURI | info:eu-repo/grantAgreement/FCT/3599-PPCDT/PTDC%2FBEX-BID%2F0899%2F2014/PT | |
| oaire.citation.issue | 11-12 | pt_PT |
| oaire.citation.startPage | 693-704 | pt_PT |
| oaire.citation.volume | 62 | pt_PT |
| oaire.fundingStream | 3599-PPCDT | |
| project.funder.identifier | http://doi.org/10.13039/501100001871 | |
| project.funder.name | Fundação para a Ciência e a Tecnologia | |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |
| relation.isProjectOfPublication | 1aa95bd5-02a2-43c2-bd5f-8bd78d049780 | |
| relation.isProjectOfPublication.latestForDiscovery | 1aa95bd5-02a2-43c2-bd5f-8bd78d049780 |